Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2011, Article ID 631079, 4 pages
Case Report

Development of Cutaneous Leishmaniasis after Leishmania Skin Test

1Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BA 40000, Brazil
2Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais, CNPq/MCT, Salvador, BA 40000, Brazil
3Cursos de Medicina e Biomedicina, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA 40000, Brazil
4Centro de Pesquisas Gonçalo Moniz, LASP, Fundação Oswaldo Cruz, Salvador, BA 40000, Brazil

Received 26 May 2011; Revised 1 September 2011; Accepted 1 September 2011

Academic Editor: Abhay R. Satoskar

Copyright © 2011 Paulo R. Machado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thirty-year-old female with a previous history of a cutaneous ulcer suspicious of leishmaniasis 20 years ago presented with a new complaint of a depressed papular lesion 8 × 7  mm in the right lower extremity. The lesion was of 10-day duration. Because early cutaneous leishmaniasis (CL) lesions may have a non-ulcerated appearance, a Leishmania skin test (LST) was performed on the forearm with a strong positive result ( 3 8 × 3 2  mm). After 8 days, the lesion in the leg, which was diagnosed as folliculitis, completely healed. However, a typical CL ulcer ( 2 6 × 2 4  mm) developed at the LST site. Histopathology of the new lesion did not identifiy parasites, but the findings were consistent with a diagnosis of CL. Further analysis identified amastigotes by immunohistochemical stain. Mononuclear cells harvested from the patient were stimulated with Leishmania antigen and showed high levels of production of both tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ): 2,943 pg/mL and 2,313 pg/mL, respectively. After 40 days of treatment with antimony and pentoxifylline, the ulcer resolved. The development of CL at the LST site suggests a strong Th1 immune response, and it is an in vivo documentation of the role of the host immune response in the pathology of CL. It teaches us that LST should be cautiously, if at all, used in patients with self-healing CL ulcers.