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Case Reports in Medicine
Volume 2011 (2011), Article ID 648217, 4 pages
http://dx.doi.org/10.1155/2011/648217
Case Report

Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association?

13rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece
22nd Department of Radiology, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece
3University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece
4Department of Pediatric Surgery, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece

Received 26 May 2011; Accepted 24 June 2011

Academic Editor: André Meégarbaneé

Copyright © 2011 Evangelos P. Misiakos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A possible association between Friedreich's ataxia (FA) and neoplastic development has been recognized. FA patients have low frataxin levels and insufficient response to oxidative stress. In these patients fibroblasts are characterized by a high rate of mutations. Herein, a case of a 39-year-old woman with FA tetraplegia, who was admitted in our department with intestinal obstruction due to a huge uterine tumor, is described. An abdominal CT revealed a huge intra-abdominal mass originating from the right cornu of the uterus. Tumor excision and adhesionlysis were performed. The histological examination of the tumor revealed a leiomyoma. FA patients seem to present with a variety of neoplasms uncommon for their young age. This is the first report of a leiomyoma originating from the genital system in a female patient with FA tetraplegia. Therefore it is important to identify neoplasms at an early stage in patients with FA and start immediate therapy.