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Case Reports in Medicine
Volume 2011, Article ID 738413, 4 pages
http://dx.doi.org/10.1155/2011/738413
Case Report

Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

1Department of Graduate Medical Education, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
2Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
3Department of Women's Oncology, Breast Program, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
4Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, USA
5Department of Oncologic Sciences, University of South Florida, Tampa, FL 33612, USA
6Pathology & Laboratory Services (113), James A Haley VA Hospital, 13000 Bruce B Downs Boulevard, Tampa, FL 33612, USA

Received 4 August 2010; Accepted 20 April 2011

Academic Editor: P. J. K. Kuppen

Copyright © 2011 Rodney E. Shackelford et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metastases to the breast from extramammary primaries are uncommon and account for 0.5–6% of all breast malignancies (Georgiannos et al., 2001, and Vizcaíno et al., 2001). Malignant melanoma, lymphoma, and lung and gastric carcinomas are the most frequently encountered nonmammary metastases to the breast in adults (Georgiannos et al., 2001, and Chaignaud et al., 1994). Primary colorectal adenocarcinoma (CRC) metastatic to the breast is extremely rare, with the medical literature having only 19 recorded cases. Typically CRC metastatic to the breast is indicative of widely disseminated disease and a poor prognosis. Here we present a case of poorly differentiated colon cancer metastatic to the breast and review the current literature on this rare event.