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Case Reports in Medicine
Volume 2011, Article ID 956089, 3 pages
Case Report

Cardiac Angiosarcoma-Associated Membranoproliferative Glomerulonephropathy

1Department of Internal Medicine, Southern Illinois University School of Medicine, 701 N. First Street, Springfield, IL 62702, USA
2Pathology Associates of Central Illinois LTD, Springfield, IL 62702, USA

Received 21 September 2010; Accepted 24 March 2011

Academic Editor: Remo Panaccione

Copyright © 2011 Lokesh Shahani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Primary cardiac angiosarcoma is a rare cardiac tumor. The initial clinical course is often asymptomatic, and metastatic disease is present in a majority of affected patients at diagnosis. We present a patient who presented with a hemorrhagic pericardial effusion. No malignant cells were evident on cytological examination. He subsequently developed membranoproliferative glomerulonephritis requiring hemodialysis. Metastatic cardiac angiosarcoma was diagnosed 5 months later. To our knowledge, this is the first reported case of paraneoplastic membranoproliferative glomerulopathy associated with cardiac angiosarcoma.