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Case Reports in Medicine
Volume 2012, Article ID 148103, 5 pages
Case Report

Metastasizing Pleomorphic Adenoma: A Fascinating Enigma

1Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Damas Hospital, Ponce School of Medicine Consortium, Ponce, PR 00717, USA
2Department of Cytotechnology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA

Received 13 August 2012; Revised 19 September 2012; Accepted 19 September 2012

Academic Editor: David W. Eisele

Copyright © 2012 Luis E. IV Santaliz-Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Among salivary gland neoplasms, metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare group of tumors. The present paper reports a case of pleomorphic adenoma (PA) in submandibular gland that, after more than 30 years of initial treatment, recurred and metastasized to ipsilateral neck lymph nodes and parotid gland. In an attempt to elucidate the malignant behavior of metastasizing pleomorphic adenoma, we performed Ki-67, p53, p16, and bcl-2 immunohistochemistry staining of our case sample. Many immunohistochemistry staining studies have been done on malignant salivary gland tumors. However, to the best of our knowledge no immunohistochemistry staining of the aforementioned markers has been previously performed on metastasizing pleomorphic adenoma.