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Case Reports in Medicine
Volume 2012, Article ID 314056, 5 pages
Case Report

Hyperuricemic Renal Failure in Nonhematologic Solid Tumors: A Case Report and Review of the Literature

Department of Internal Medicine, North Shore Medical Centre (NSMC), Salem, MA 01970, USA

Received 18 February 2012; Revised 27 March 2012; Accepted 29 March 2012

Academic Editor: Estella M. Matutes

Copyright © 2012 Neeraj Saini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous tumor lysis syndrome (STLS) without any cytotoxic chemotherapy rarely occurs in solid tumors. We describe a case of STLS in a metastatic adenocarcinoma of unknown primary and review the literature of STLS in solid non-hematologic tumors to identify various risk factors for pathogenesis of this entity.