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Case Reports in Medicine
Volume 2012, Article ID 314697, 6 pages
http://dx.doi.org/10.1155/2012/314697
Case Report

Liposarcoma of the Nasopharynx: Diagnosis and Management of a Rare Diagnostic Entity

11st Department of Otolaryngology Head and Neck Surgery, Hippokration General Hospital, School of Medicine, National and Kapodistrian Unversity of Athens, 114 Vas. Sophias Avnue, 11527 Athens, Greece
2Department of Pathology, Hipporation General Hospital, 114 Vas. Sophias Avnue, 11527 Athens, Greece

Received 30 June 2011; Revised 11 January 2012; Accepted 20 January 2012

Academic Editor: Valerae O. Lewis

Copyright © 2012 George X. Papacharalampous et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Liposarcoma is one of the most frequently occurring soft tissue sarcomas in adulthood. The majority of liposarcomas arise in the lower extremities and retroperitoneum, while the incidence of this tumor in the head and neck region is reported to be extremely low, comprising 1.8%–6.2% of all cases. Nasopharyngeal liposarcoma is exceptionally rare, with only three cases having been reported in the English literature. This paper presents a case of a nasopharyngeal liposarcoma, treated with endoscopic tumor debulking, followed by adjuvant chemotherapy and radiotherapy, and reviews the current literature with regard to diagnosis and management of such lesions. Most authors agree that the imaging modality of choice is magnetic resonance imaging. Although radiographic findings usually support diagnosis, the imaging characteristics of such lesions may considerably vary, depending on the histological subtype and the macroscopic appearance of the tumor. The treatment of choice is complete surgical excision when possible. Although the role of postoperative radiotherapy is not clearly defined, some authors support that radiotherapy might delay or prevent local recurrence. However, there is no adequate evidence that the combination of surgery and radiotherapy lowers the possibility of distant metastasis of the head and neck liposarcomas. The role of adjuvant or neoadjuvant chemotherapy still remains controversial.