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Case Reports in Medicine
Volume 2012, Article ID 346039, 3 pages
Case Report

Severe Primary HSV-2 in a Perinatal HIV-Infected Woman with Advanced Immunosuppression

1Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
2Divisions of Adult and Pediatric Infectious Diseases, Departments of Internal Medicine and Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA

Received 19 April 2012; Accepted 3 July 2012

Academic Editor: Ingo W. Husstedt

Copyright © 2012 Lana Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herpes simplex virus type 2 (HSV-2) is most commonly associated with mucocutaneous manifestations; however, coinfections with HIV may be associated with atypical and more severe presentations of clinical disease. We present a case of a young woman with advanced perinatally acquired AIDS presenting with severe purulent pharyngitis, fevers, and toxic appearance with a subsequent diagnosis of disseminated primary HSV-2 infection in multiple noncontiguous mucocutaneous sites. This case highlights an unusual presentation of the protean nature of primary HSV infection and the potential severity of illness in patients with advanced immunosuppression.