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Case Reports in Medicine
Volume 2012, Article ID 593578, 2 pages
http://dx.doi.org/10.1155/2012/593578
Case Report

Use of Daptomycin for the Treatment of Methicillin-Resistant Coagulase-Negative Staphylococcal Ventriculitis

1Division of Infectious Diseases, Department of Medicine, New York Hospital Queens, Flushing, NY 11355, USA
2Department of Pharmacy, New York Hospital Queens, Flushing, NY 11355, USA
3Division of Neurosurgery, Department of Surgery, New York Hospital Queens, Flushing, NY 11355, USA
4Department of Pharmacy, Hartford Hospital, Hartford, CT 06102, USA

Received 19 January 2012; Accepted 13 March 2012

Academic Editor: Dianne L. Atkins

Copyright © 2012 Mohamed Erritouni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coagulase-negative staphylococci (CoNS) are the main pathogens causing hospital-acquired external-ventricular-drain- (EVD-) and lumbar-drain- (LD-) associated meningitis and ventriculitis. The treatment of these infections can be challenging and may require combination of intraventricular and intravenous administration of antibiotics. Limited animal data demonstrate rapid daptomycin bactericidal activity, adequate penetration in the setting of inflamed meninges, and extended half-life in the ventricles Steenbergen et al. (2009). There are limited clinical data using daptomycin intravenously and/or intraventricularly for the treatment of central nervous system infections (CNS) Elvy et al. (2008), Stucki et al. (2007), Lee et al. (2008) and Wallace et al. (2009). We report here our experience in the treatment of an EVD-related infection.