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Case Reports in Medicine
Volume 2013, Article ID 159309, 3 pages
Case Report

Bleeding in a 43 Year Old Female: A Rare Disease

Department of Internal Medicine, Saint Joseph Hospital, 2900 N. Lake Shore Drive, Chicago, IL 60657, USA

Received 4 January 2013; Accepted 15 March 2013

Academic Editor: Louis M. Aledort

Copyright © 2013 Nwabundo Nwankwo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 43-year-old gravida 2 para 2 Caucasian female with a past medical history of menorrhagia secondary to uterine fibroids and thyroid disease presented to the emergency department with complaints of bruising in her oral mucosa and vaginal bleeding. One week prior to this presentation, she was transfused with two units of packed red blood cells because of symptomatic anemia secondary to menorrhagia. Physical examination was normal, except for petechiae on the abdomen and the lower extremities as well as purpuric lesions on the buccal mucosa. Blood work revealed thrombocytopenia. Posttransfusion thrombocytopenia was suspected. The patient was transfused with washed and leukoreduced platelets and treated with steroids and intravenous immunoglobulins. Laboratory studies demonstrated that she was homozygous for the HPA-Ib/1b platelet gene and positive antibodies against class 1 HLA and platelet glycoproteins. The patient responded well to treatment, with normalization of her platelet count.