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Case Reports in Medicine
Volume 2013 (2013), Article ID 348628, 4 pages
http://dx.doi.org/10.1155/2013/348628
Case Report

Multifocal Buruli Ulcer Associated with Secondary Infection in HIV Positive Patient

Department of Dermatology and Infectiology, School of Medicine, Felix Houphouét Boigny University of Abidjan, BP 01 V166 Abidjan 01, Cote d’Ivoire

Received 20 June 2013; Revised 6 December 2013; Accepted 12 December 2013

Academic Editor: T. Ottenhoff

Copyright © 2013 Kassi Komenan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Buruli ulcer is a chronic and infectious skin disease, caused by Mycobacterium ulcerans. It leads to large skin ulceration and sometimes bone infection which is responsible for deformities. Here, we report a case of multifocal form of Buruli ulcer associated with secondary infection in a 46-year-old human immunodeficiency virus (HIV) positive woman. The antimycobacterial drugs combined to surgery allowed curing this multifocal case and rose up two relevant issues: the susceptibility of immune reconstitution inflammatory syndrome (IRIS) occurrence and Mycobacterium dissemination. The deep immune depression, the underline biological, and clinical disorders of the patient might contribute to IRIS occurrence and Buruli ulcer dissemination. Future investigations have to be conducted on the mechanism of IRIS on set and on Mycobacterium ulcerans dissemination after ARV drugs initiation and the patient related underline clinical or biological disorders.