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Case Reports in Medicine
Volume 2013, Article ID 392609, 4 pages
http://dx.doi.org/10.1155/2013/392609
Case Report

Multiple Skeletal Muscle Metastases from Colon Carcinoma Preceded by Paraneoplastic Dermatomyositis

1Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto, 1-71100 Foggia, Italy
2General Surgery Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto, 1-71100 Foggia, Italy
3Nuclear Medicine Unit, Riuniti Hospital, Viale Pinto, 1-71100 Foggia, Italy
4Radiology Unit, Department of Clinical and Experimental Medicine, University of Foggia, Viale Pinto, 1-71100 Foggia, Italy
5Pathology Unit, Department of Clinical and Experimental Medicine, University of Foggia, Viale Pinto, 1-71100 Foggia, Italy

Received 5 April 2013; Revised 23 June 2013; Accepted 8 July 2013

Academic Editor: Jahn M. Nesland

Copyright © 2013 Matteo Landriscina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Skeletal muscle metastases are very rare events in colorectal carcinoma. By contrast, dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations and a well-recognized association with several human malignancies and, among others, colorectal cancer. Here, we report the case of a 71-year-old woman with paraneoplastic dermatomyositis followed by the development of a metastatic colon cancer. Interestingly, this patient developed multiple skeletal metastases which were preceded by the worsening of systemic symptoms of dermatomyositis. This observation suggests that, while muscle tissue is usually resistant to the development of tumor metastases, the inflammatory and immune response which characterizes and boosts paraneoplastic myopathy may represent a favorable soil for tumor cell invasion and metastasization to skeletal muscles.