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Case Reports in Medicine
Volume 2013 (2013), Article ID 461485, 2 pages
Microscopic Colitis with Macroscopic Endoscopic Findings
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, East Tennessee State University, P.O. Box 70622, Johnson City, TN 37614, USA
2Department of Internal Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Received 6 February 2013; Accepted 25 March 2013
Academic Editor: Gianfranco D. Alpini
Copyright © 2013 Atif Saleem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Microscopic Colitis (MC) is characterized by chronic watery diarrhea, grossly normal appearing colonic mucosa during conventional white light endoscopy, and biopsy showing microscopic inflammation. We report a case of collagenous colitis with gross endoscopic findings.
1. Case Report
A 71-year-old female with past medical history of coronary artery disease, carotid artery disease, hypertension, and diabetes mellitus type 2 was being evaluated for recurrent intermittent diarrhea. Patient denied any abdominal pain, weight loss, or any blood in stool. Patient was not on any medications and lab work was within normal limits. Colonoscopy was required to further evaluate patient’s diarrhea. Colonoscopy revealed multiple scattered segments throughout the colon with increased nodularity and loss of vascular markings in the hepatic flexure, descending colon and cecum (Figures 1(a) and 1(b)). These findings were more pronounced in cecum. Colonoscopy findings were reported as nonspecific colitis involving scattered segments in the colon, consistent with a Crohn's disease. Multiple biopsies were taken from both affected and nonaffected areas of the colon for pathologic determination.
Microscopic examination showed lymphocytic colitis with marked thickening of the superficial collagen table consistent with collagenous colitis. The submucosal collagen was dense and paucicellular with several entrapped lymphocytes and capillaries (red arrow). The lamina propria displays an increase in eosinophils, plasma cells, and lymphocytes (black arrow) (Figure 2).
Microscopic Colitis (MC) is characterized by chronic watery diarrhea, grossly normal appearing colonic mucosa during conventional white light endoscopy, and biopsy showing microscopic inflammation. It accounts for 4%–13% of patients evaluated for chronic diarrhea and divided into lymphocytic and collagenous colitis . MC is usually considered disease of the elderly and patients with age of more than 65 years have five times higher risk for MC. Female predominance has been noted particularly for collagenous colitis . Certain medications such as NSAIDs, PPIs, and SSRIs, as well as autoimmune disease such as thyroid disease, and celiac disease are associated with increased risk of MC [1, 2].
Although identical clinically, both types of colitis have distinct microscopic findings. Lymphocytic colitis is characterized by intraepithelial lymphocytosis (more than 20 lymphocytes for every 100 epithelial cells) while collagenous colitis is diagnosed by thickening of subepithelial collagen layer of more than 10 micrometer .
By definition colonic mucosa has a normal appearance in MC. Yet distinct endoscopic findings, particularly for collagenous colitis, have been described in the literature. These findings include alteration of mucosal vascular pattern, mucosal abnormalities such as red spots, increased mucosal nodularity, or textural alteration, and pseudomembranes .
Recent advance in endoscopy may enhance the ability to detect MC. A newly developed post processing light filters such as i-Scan (Pentax, Japan) helps to enhance the visualization of mucosal pattern and vascular architecture. Chromoendoscopy using indigocarmine dye sprays may show a mosaic pattern of mucosa in lymphocytic colitis and a nodular, grooved pattern in collagenous colitis . These new techniques can increase the yield of endoscopic diagnosis of MC by targeted biopsy compared to random biopsies at conventional white light endoscopy .
Microscopic Colitis is traditionally known to have normal colonic mucosa on endoscopy. Recent advance in endoscopic techniques has shown that various mucosal abnormalities such as alteration of mucosal vascular pattern and increased mucosal nodularity are associated with MC. These newer techniques will allow us to get targeted biopsy, which will increase the yield of endoscopic diagnosis of MC.
Conflict of Interests
The authors declare that they have no conflict of interests.
All authors participated fully in the conception, development, and creation of this paper. All authors read and approved the final version of the paper.
The authors are grateful to Brian Klazynski, MD of pathology department for providing images of histopathology stains.
- D. S. Pardi, T. C. Smyrk, W. J. Tremaine, and W. J. Sandborn, “Microscopic colitis: a review,” American Journal of Gastroenterology, vol. 97, no. 4, pp. 794–802, 2002.
- J. J. Williams, P. L. Beck, C. N. Andrews, D. B. Hogan, and M. A. Storr, “Microscopic colitis—a common cause of diarrhoea in older adults,” Age and Ageing, vol. 39, no. 2, Article ID afp243, pp. 162–168, 2010.
- A. Koulaouzidis and A. A. Saeed, “Distinct colonoscopy findings of microscopic colitis: not so microscopic after all?” World Journal of Gastroenterology, vol. 17, no. 37, pp. 4157–4165, 2011.
- M. Iacucci and S. Urbanski, “Recognition of microscopic colitis at colonoscopy,” Canadian Journal of Gastroenterology, vol. 26, no. 4, pp. 183–184, 2012.