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Case Reports in Medicine
Volume 2013 (2013), Article ID 798358, 6 pages
http://dx.doi.org/10.1155/2013/798358
Case Report

Primary Spinal Germ Cell Tumors: A Case Analysis and Review of Treatment Paradigms

1Department of Neurosurgery, Stanford University School of Medicine, Edwards Building, Neurosurgery Mailroom, 300 Pasteur Drive, Stanford, CA 94305-5487, USA
2Department of Pathology, Santa Clara Valley Medical Center (SCVMC), 751 South Bascom Ave., San Jose, CA 95128, USA
3Department of Radiation Oncology, Santa Clara Valley Medical Center (SCVMC), 751 South Bascom Ave., San Jose, CA 95128, USA

Received 11 July 2013; Revised 2 September 2013; Accepted 12 September 2013

Academic Editor: Sarkis Meterissian

Copyright © 2013 Joshua J. Loya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Borg, “Germ cell tumours of the central nervous system in children—controversies in radiotherapy,” Medical and Pediatric Oncology, vol. 40, no. 6, pp. 367–374, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Hanakita, A. Takenobu, A. Kambe, T. Watanabe, M. Shin, and A. Teraoka, “Intramedullary recurrence of germinoma in the spinal cord 15 years after complete remission of a pineal lesion: case report,” Journal of Neurosurgery, vol. 16, no. 5, pp. 513–515, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Kahn, J. Fridley, A. J. Patel et al., “Disseminated germinoma in the brain and cervical spinal cord 10 years after radiographic resolution of pineal germinoma,” Journal of Clinical Neuroscience, vol. 19, pp. 1055–1057, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Ogawa, Y. Yoshii, N. Shikama et al., “Spinal recurrence from intracranial germinoma: risk factors and treatment outcome for spinal recurrence,” International Journal of Radiation Oncology Biology Physics, vol. 72, no. 5, pp. 1347–1354, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Hisa, S. Morinaga, and Y. Kobayashi, “Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy,” Cancer, vol. 55, no. 12, pp. 2845–2849, 1985. View at Google Scholar · View at Scopus
  6. J. Zhu, Y. Gao, W. Zheng, and J. Yang, “Intramedullary spinal cord germinoma: a case report,” Chinese Medical Journal, vol. 115, no. 9, pp. 1418–1419, 2002. View at Google Scholar · View at Scopus
  7. D. D. Slagel, J. A. Goeken, C. A. Platz, and S. A. Moore, “Primary germinoma of the spinal cord: a case report with 28-year follow-up and review of the literature,” Acta Neuropathologica, vol. 90, no. 6, pp. 657–659, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Aoyama, K. Hida, N. Ishii, T. Seki, J. Ikeda, and Y. Iwasaki, “Intramedullary spinal cord germinoma-2 case reports,” Surgical Neurology, vol. 67, no. 2, pp. 177–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. D. J. Chute, E. C. Burton, I. A. Klement, J. G. Frazee, and H. V. Vinters, “Primary intramedullary spinal cord germinoma: case report,” Journal of Neuro-Oncology, vol. 63, no. 1, pp. 69–73, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. J. H. Huang, I. Tsui, A. R. Judkins, E. Simon, J. K. Birknes, and L. N. Sutton, “Intramedullary cervical spine germinoma: case report,” Neurosurgery, vol. 55, no. 6, p. 1432, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Kiyuna, T. Toda, A. M. Sadi, Z. Toyoda, and Y. Nakashima, “A rare case of extramedullary spinal cord germinoma,” Pathology International, vol. 49, no. 7, pp. 633–637, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Massimino, L. Gandola, F. Spreafico et al., “Unusual primary secreting germ cell tumor of the spine: case report,” Journal of Neurosurgery, vol. 5, no. 1, pp. 65–67, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Kinoshita, K. Akatsuka, M. Ohtake, H. Kamitani, and T. Watanabe, “Primary intramedullary spinal cord germinoma,” Neurologia Medico-Chirurgica, vol. 50, no. 7, pp. 592–594, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Takahashi, H. Koyama, T. Matsubara, H. Murata, K. Miura, and A. Nagano, “Mixed germinoma and choriocarcinoma in the intramedullary spinal cord: case report and review of the literature,” Journal of Neuro-Oncology, vol. 76, no. 1, pp. 71–75, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Yamagata, T. Takami, N. Tsuyuguchi, T. Goto, K. Wakasa, and K. Ohata, “Primary intramedullary spinal cord germinoma: diagnostic challenge and treatment strategy—two case reports,” Neurologia Medico-Chirurgica, vol. 49, no. 3, pp. 128–133, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Kawano and T. Tsujimura, “Intramedullary spinal cord germinoma,” Arch Histopathol Differ Diagn, vol. 2, pp. 52–54, 1995. View at Google Scholar
  17. Y. Itoh, K. Mineura, H. Sasajima, and M. Kowada, “Intramedullary spinal cord germinoma: case report and review of the literature,” Neurosurgery, vol. 38, no. 1, pp. 187–191, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Miyauchi, K. Matsumoto, E. Kohmura, T. Doi, K. Hashimoto, and K. Kawano, “Primary intramedullary spinal cord germinoma: case report,” Journal of Neurosurgery, vol. 84, no. 6, pp. 1060–1061, 1996. View at Google Scholar · View at Scopus
  19. Y. Nakata, A. Yagishita, and N. Arai, “Two patients with intraspinal germinoma associated with Klinefelter syndrome: case report and review of the literature,” American Journal of Neuroradiology, vol. 27, no. 6, pp. 1204–1210, 2006. View at Google Scholar · View at Scopus
  20. A. Biswas, T. Puri, S. Goyal et al., “Spinal intradural primary germ cell tumour-review of literature and case report,” Acta Neurochirurgica, vol. 151, no. 3, pp. 277–284, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. I. H. Tekkök and A. Sav, “Aggressive spinal germinoma with ascending metastases,” Journal of Neuro-Oncology, vol. 75, no. 2, pp. 135–141, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. O. Ganslandt, M. Buchfelder, and G. G. Grabenbauer, “Primary spinal germinoma in a patient with concomitant Klinefelter's syndrome,” British Journal of Neurosurgery, vol. 14, no. 3, pp. 252–255, 2000. View at Google Scholar · View at Scopus
  23. S. Matsuoka, M. Itoh, T. Shinonome, and A. Tanimura, “Intramedullary spinal cord germinoma: case report,” Surgical Neurology, vol. 35, no. 2, pp. 122–126, 1991. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Nagasawa, H. Kikuchi, J. Yamashita, and K. Mitsuno, “Intracranial and spinal germinomas occurring four years after spinal cord germinoma. Case report,” Neurologia Medico-Chirurgica, vol. 31, no. 11, pp. 729–731, 1991. View at Google Scholar · View at Scopus
  25. T. Sasaki, T. Amano, M. Takao, M. Shibata, N. Shigematsu, and Y. Fukuuchi, “A case of intramedullary spinal cord tumor producing human chorionic gonadotropin,” Journal of Neuro-Oncology, vol. 56, no. 3, pp. 247–250, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Watanabe, T. Horikoshi, H. Naganuma, E. Satoh, and H. Nukui, “Intramedullary spinal cord germinoma expresses the protooncogene c-kit,” Acta Neurochirurgica, vol. 147, no. 3, pp. 303–308, 2005. View at Google Scholar · View at Scopus
  27. M. Hata, I. Ogino, K. Sakata, H. Murata, N. Kawano, and S. Matsubara, “Intramedullary spinal cord germinoma: case report and review of the literature,” Radiology, vol. 223, no. 2, pp. 379–383, 2002. View at Google Scholar · View at Scopus
  28. K. Hanafusa, H. Shibuya, M. Abe, K. Yamaura, and S. Suzuki, “Intramedullary spinal cord germinoma. Case report and review of the literature,” RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, vol. 159, no. 2, pp. 203–204, 1993. View at Google Scholar · View at Scopus
  29. Y. Matsuyama, T. Nagasaka, K. Mimatsu, K. Inoue, K. Mii, and H. Iwata, “Intramedullary spinal cord germinoma,” Spine, vol. 20, no. 21, pp. 2338–2340, 1995. View at Google Scholar · View at Scopus
  30. L. Horvath, D. McDowell, G. Stevens, R. Parkinson, S. McCarthy, and M. Boyer, “Case 2. Seminoma of the conus medullaris,” Journal of Clinical Oncology, vol. 19, no. 3, pp. 911–915, 2001. View at Google Scholar · View at Scopus
  31. T. L. Goodwin, K. Sainani, and P. G. Fisher, “Incidence patterns of central nervous system germ cell tumors: a SEER study,” Journal of Pediatric Hematology/Oncology, vol. 31, no. 8, pp. 541–544, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Uematsu, Y. Tsuura, K. Miyamoto, T. Itakura, S. Hayashi, and N. Komai, “The recurrence of primary intracranial germinomas. Special reference to germinoma with STGC (syncytiotrophoblastic giant cell),” Journal of Neuro-Oncology, vol. 13, no. 3, pp. 247–256, 1992. View at Google Scholar · View at Scopus
  33. C. Balmaceda, G. Heller, M. Rosenblum et al., “Chemotherapy without irradiation—a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial,” Journal of Clinical Oncology, vol. 14, no. 11, pp. 2908–2915, 1996. View at Google Scholar · View at Scopus
  34. Y. Itoyama, M. Kochi, S. Yamashiro, K. Yoshizato, J. Kuratsu, and Y. Ushio, “Combination chemotherapy with cisplatin and etoposide for hematogenous spinal metastasis of intracranial germinoma. Case report,” Neurologia Medico-Chirurgica, vol. 33, no. 1, pp. 28–31, 1993. View at Google Scholar · View at Scopus
  35. P. S. G. J. Hupperets, H. F. Defesche, L. M. de Bruijckere, and A. Twijnstra, “The role of chemotherapy in intracranial germinoma: a case report,” Annals of Oncology, vol. 10, no. 6, pp. 723–726, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. Sawamura, H. Shirato, J. Ikeda et al., “Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma,” Journal of Neurosurgery, vol. 88, no. 1, pp. 66–72, 1998. View at Google Scholar · View at Scopus
  37. C. R. Pinkerton, V. Broadbent, A. Horwich et al., “‘JEB’—a carboplatin based regimen for malignant germ cell tumours in children,” British Journal of Cancer, vol. 62, no. 2, pp. 257–262, 1990. View at Google Scholar · View at Scopus