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Case Reports in Medicine
Volume 2013, Article ID 804136, 3 pages
Case Report

A Case of the Large Cell Neuroendocrine Carcinoma of the Urinary Bladder

Department of Urology, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu City, Oita 874-0011, Japan

Received 30 September 2012; Revised 25 February 2013; Accepted 17 March 2013

Academic Editor: Maxwell V. Meng

Copyright © 2013 Shinro Hata and Yoshihisa Tasaki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Definite treatment strategy has not been established and prognosis of the disease is not clear yet. We report a case of primary LCNEC of the urinary bladder here with some review of the literature. The patient was a 84-year-old man. He underwent transurethral resection of bladder tumor (TURBT). Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive CD 56, synaptophysin, and chromogranin A (LCNEC). After TURBT, he has no sign of recurrence for 8 months. We have to strictly observe the progress because LCNEC is very aggressive.