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Case Reports in Medicine
Volume 2013, Article ID 935172, 5 pages
http://dx.doi.org/10.1155/2013/935172
Case Report

The Occurrence or Fibrillary Glomerulonephritis in Patients with Diabetes Mellitus May Not Be Coincidental: A Report of Four Cases

1Nephrology Department, Dr. Negrin University Hospital, Las Palmas de Gran Canaria University, Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain
2Nephrology Department, University Hospital Materno-Insular, Spain
3Pathology Department, Dr. Negrin University Hospital, Las Palmas de Gran Canaria University, Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain

Received 2 March 2013; Revised 15 April 2013; Accepted 28 April 2013

Academic Editor: Christian Koch

Copyright © 2013 Fayna González-Cabrera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although clinical presentation of fibrillary glomerulonephritis is similar to most forms of glomerulonephritis, it is usually difficult to make the diagnosis. Clinical manifestations include proteinuria, microscopic haematuria, nephrotic syndrome, and impairment of renal function. A diagnosis of fibrillary glomerulonephritis is only confirmed by renal biopsy and it must comprise electronmicroscopy-verified ultrastructural findings. We report four cases between 45–50 years old with documented type 2 diabetes mellitus (T2DM) and arterial hypertension. All patients were found to have fibrils on kidney biopsy. The differential diagnosis of fibrils in the setting of diabetes mellitus is also discussed.