Unloading of Right Ventricle and Clinical Improvement after Ultrasound-Accelerated Thrombolysis in Patients with Submassive Pulmonary Embolism

Table 1

Summary of the patients’ data.

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Presenting symptoms	Dyspnea	Syncope	Dyspnea	Dyspnea	Dyspnea
Source of thrombus	DVT	DVT	DVT	Unknown	Unknown
Pro-BNP (pg/mL)	6853	149	1193	7511	603
Troponins (ng/mL)	1.09	0.02	0.02	0.02	0.02
D-Dimer (ng/mL)	4060	5000	N/A	N/A	2072
CT-scan findings	Right middle and lower lobe emboli	Saddle emboli	Bilateral emboli within main pulmonary arteries	Bilateral emboli within main pulmonary arteries	Saddle emboli
Echocardiogram (RVSP in mmHg)	Hypokinetic RV enlargement (75), RV/LV > 1	Markedly dilated and hypokinetic RV (70), RV/LV > 1	RV/LV > 1, severe pulmonary hypertension (73), and hypokinetic RV	Right ventricular strain, straightening of the septum (57), RV/LV > 1	Hypokinesia of right ventricular free wall (60), RV/LV > 1
Alteplase amount (per PA)	12	10	13	12	6
Follow-up echocardiogram (RVSP in mmHg)	Improved function of the right ventricle (50), RV/LV < 1	Mild RV dyskinesia (62), RV/LV < 1	No RV strain or pulmonary hypertension (35), RV/LV < 1	Mildly depressed RV function (40),; RV/LV < 1	Resolution of RV hypokinesia (45), RV/LV < 1
Presenting symptoms at the time of discharge	Resolved	Resolved	Resolved	Resolved	Resolved

DVT = deep vein thrombosis; BNP = brain-natriuretic peptide; sPAP = systolic pulmonary artery pressure during right heart catheterization; RV = right ventricle; LV = left ventricle; PA = pulmonary artery; RVSP = right ventricular systolic pressure.