Chronic Hepatitis C Therapy in Liver Cirrhosis Complicated by Telaprevir-Induced DRESS
Table 2
Naranjo adverse drug reaction probability scale for each DRESS case. Total scores in cases A and B were 7 and 6, respectively. Scores from 5 to 8 suggest Probable cases of DRESS. Bold cells are positive findings [11].
Number
The Naranjo adverse drug reaction probability scale
Patient A
Patient B
Yes
No
Do not know
Yes
No
Do not know
1
Are there previous conclusive reports of this reaction?
+1
0
0
+1
0
0
2
Did the adverse event appear after the drug was given?
+2
−1
0
+2
−1
0
3
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?
+1
0
0
+1
0
0
4
Did the adverse reaction reappear upon readministering the drug?
+2
−1
0
+2
−1
0
5
Were there other possible causes for the reaction?
−1
+2
0
−1
+2
0
6
Did the adverse reaction reappear upon administration of placebo?
−1
+1
0
−1
+1
0
7
Was the drug detected in the blood or other fluids in toxic concentrations?
+1
0
0
+1
0
0
8
Was the reaction worsened upon increasing the dose? Or, was the reaction lessened upon decreasing the dose?
+1
0
0
+1
0
0
9
Did the patient have a similar reaction to the drug or a related agent in the past?
+1
0
0
+1
0
0
10
Was the adverse event confirmed by any other objective evidence?
