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Case Reports in Medicine
Volume 2014, Article ID 453874, 8 pages
Case Report

A New Case of Syringocystadenocarcinoma Papilliferum: A Rare Pathology for a Wide-Ranging Comprehension

1Department of Morphology, Surgery and Experimental Medicine, Section of Anatomic Pathology, University of Ferrara and S. Anna University Hospital Via Aldo Moro, 8, 44124 Cona, Ferrara, Italy
2Department of Medical Sciences, Section of Pharmacology and Neuroscience Center, University of Ferrara, Via Aldo Moro, 8, 44124 Cona, Italy
3National Institute of Neuroscience, Italy
4Ri.MED Foundation, Palermo, Italy

Received 30 December 2013; Revised 21 April 2014; Accepted 22 April 2014; Published 15 May 2014

Academic Editor: Jeffrey M. Weinberg

Copyright © 2014 Beatrice Paradiso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

EMT represents a general physiopathologic event implicated in all types of carcinoma and provides them an additional survival advantage. By means of EMT the epithelial tumor cells can transdifferentiate into myofibroblasts, producing the desmoplastic stroma which is essential for tumor growth, invasion and metastasis. During the EMT process, cancer epithelial cells acquire stem cell-like traits and appear positive for putative cancer stem cell (CSC) markers, resulting in a migratory cell phenotype. So EMT- like properties of carcinoma, showed by c- kit staining, are more persuasive when they are associated with an increase of putative stemness marker expression. For this reason we have analyzed nestin, CD44 and CD133 antigens.

  1. Supplementary Figures