One Patient, Two Uncommon B-Cell Neoplasms: Solitary Plasmacytoma following Complete Remission from Intravascular Large B-Cell Lymphoma Involving Central Nervous System
Figure 4
(a) Intravascular large B-cell lymphoma of brain. Neoplastic cells express bcl2 but lack cyclin D1 expression. In situ hybridization shows polytypic immunoglobulin light chain expression in the perivascular reactive plasma cells but not within intravascular neoplastic B cells. (b) Spinal plasma cell neoplasm. Apart from expression of CD138, the spinal plasma cell neoplasm displays expression of PAX5 and cyclin D1 but not CD56. In situ hybridization confirms lambda immunoglobulin light chain restriction.
