Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2014, Article ID 637492, 7 pages
http://dx.doi.org/10.1155/2014/637492
Case Report

Mucormycosis in Patients with Inflammatory Bowel Disease: Case Series and Review of the Literature

1Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
3Altru Medical Center, Grand Forks, ND 58201, USA
4Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55902, USA

Received 20 February 2014; Accepted 22 March 2014; Published 27 April 2014

Academic Editor: Yasuhiko Sugawara

Copyright © 2014 Maheen Z. Abidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. J. Walsh, B. E. Bloom, and D. P. Kontoyiannis, “Meeting the challenges of an emerging pathogen: the Henry Schueler 41&9 foundation international forum on mucormycosis,” Clinical Infectious Diseases, vol. 54, no. 1, pp. S1–S4, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Chamilos, R. E. Lewis, and D. P. Kontoyiannis, “Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis,” Clinical Infectious Diseases, vol. 47, no. 4, pp. 503–509, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. D. P. Kontoyiannis and R. E. Lewis, “How I treat mucormycosis,” Blood, vol. 118, no. 5, pp. 1216–1224, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. S. Ibrahim, B. Spellberg, T. J. Walsh, and D. P. Kontoyiannis, “Pathogenesis of mucormycosis,” Clinical Infectious Diseases, vol. 54, no. 1, pp. S16–S22, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. D. P. Kontoyiannis and R. E. Lewis, “Invasive zygomycosis: update on pathogenesis, clinical manifestations, and management,” Infectious Disease Clinics of North America, vol. 20, no. 3, pp. 581–607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Spellberg, J. Edwards Jr., and A. Ibrahim, “Novel perspectives on mucormycosis: pathophysiology, presentation, and management,” Clinical Microbiology Reviews, vol. 18, no. 3, pp. 556–569, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Spellberg, T. J. Walsh, D. P. Kontoyiannis, J. J. Edwards Jr., and A. S. Ibrahim, “Recent advances in the management of mucormycosis: from bench to bedside,” Clinical Infectious Diseases, vol. 48, no. 12, pp. 1743–1751, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. S. P. L. Travis, E. F. Stange, M. Lémann et al., “European evidence based consensus on the diagnosis and management of Crohn's disease: current management,” Gut, vol. 55, no. 1, pp. i16–i35, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. W. Alderson, T. G. Van Dinter Jr., M. J. Opatowsky, and E. C. Burton, “Disseminated aspergillosis following infliximab therapy in an immunosuppressed patient with Crohn's disease and chronic hepatitis C: a case study and review of the literature,” MedGenMed, vol. 7, no. 3, p. 7, 2005. View at Google Scholar · View at Scopus
  10. G. C. Wall and B. I. Leman, “Mucormycosis in a crohn's disease patient treated with infliximab,” Digestion, vol. 80, no. 3, pp. 182–184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. M. Roden, T. E. Zaoutis, W. L. Buchanan et al., “Epidemiology and outcome of zygomycosis: a review of 929 reported cases,” Clinical Infectious Diseases, vol. 41, no. 5, pp. 634–653, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. S. M. Devlin, B. Hu, and A. Ippoliti, “Mucormycosis presenting as recurrent gastric perforation in a patient with Crohn's disease on glucocorticoid, 6-mercaptopurine, and infliximab therapy,” Digestive Diseases and Sciences, vol. 52, no. 9, pp. 2078–2081, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Tehmeena, W. Hussain, H. R. Zargar, A. R. Sheikh, and S. Iqbal, “Primary cutaneous mucormycosis in an immunocompetent host,” Mycopathologia, vol. 164, no. 4, pp. 197–199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Hyvernat, B. Dunais, F. Burel-Vandenbos, S. Guidicelli, G. Bernardin, and M. Gari-Toussaint, “Fatal peritonitis caused by Rhizopus microsporus,” Medical Mycology, vol. 48, no. 8, pp. 1096–1098, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Ibanez, R. Serrano-Heranz, I. Sanchez-Zaballos, P. Carbonero, and G. Lopez, “Disseminated mucormycosis due to Absidia corymbifera in a patient with inflammatory bowel disease,” Clinical Microbiology and Infection, vol. 3, no. 2, pp. 268–270, 1997. View at Google Scholar · View at Scopus
  16. A. J. Hunter and R. E. Bryant, “Abdominal wall mucormycosis successfully treated with amphotericin and itraconazole,” Journal of Infection, vol. 44, no. 3, pp. 203–204, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Gubarev, J. Separovic, V. Gasparovic, and I. Jelic, “Successful treatment of mucormycosis endocarditis complicated by pulmonary involvement,” Thoracic and Cardiovascular Surgeon, vol. 55, no. 4, pp. 257–258, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Virmani, D. H. Connor, and H. A. McAllister, “Cardiac mucormycosis. A report of five patients and review of 14 previously reported cases,” American Journal of Clinical Pathology, vol. 78, no. 1, pp. 42–47, 1982. View at Google Scholar · View at Scopus
  19. M. Muqeetadnan, A. Rahman, S. Amer, S. Nusrat, S. Hassan, and S. Hashmi, “Pulmonary mucormycosis: an emerging infection,” Case Reports in Pulmonology, vol. 2012, Article ID 120809, 3 pages, 2012. View at Publisher · View at Google Scholar
  20. D. P. Kontoyiannis, M. S. Lionakis, R. E. Lewis et al., “Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases,” Journal of Infectious Diseases, vol. 191, no. 8, pp. 1350–1360, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Skiada, F. Lanternier, A. H. Groll et al., “Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3),” Haematologica, vol. 98, no. 4, pp. 492–504, 2013. View at Publisher · View at Google Scholar
  22. B. Spellberg, A. Ibrahim, E. Roilides et al., “Combination therapy for mucormycosis: why, what, and how?” Clinical Infectious Diseases, vol. 54, no. 1, pp. S73–S78, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. A. S. Ibrahim, T. Gebremariam, Y. Fu, J. E. Edwards Jr., and B. Spellberg, “Combination echinocandin-polyene treatment of murine mucormycosis,” Antimicrobial Agents and Chemotherapy, vol. 52, no. 4, pp. 1556–1558, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Spellberg, Y. Fu, J. E. Edwards Jr., and A. S. Ibrahim, “Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice,” Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, pp. 830–832, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Reed, R. Bryant, A. S. Ibrahim et al., “Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis,” Clinical Infectious Diseases, vol. 47, no. 3, pp. 364–371, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Y. W. Lee, S. B. Mossad, and K. A. Adal, “Pulmonary mucormycosis: the last 30 years,” Archives of Internal Medicine, vol. 159, no. 12, pp. 1301–1309, 1999. View at Publisher · View at Google Scholar · View at Scopus