Fecal Transplantation Treatment of Antibiotic-Induced, Noninfectious Colitis and Long-Term Microbiota Follow-Up
Table 1
Mucosal bacteria with >2-fold change in relative abundance after FMT and constituting >0.01% of the microbiota.
Phylum/cluster
Increased bacterial groups in colonic
Fold-change B0 to B1
Increased in feces F14 m and F2 w–7
Actinobacteria
Bifidobacterium spp.
2.2
Yes
Bacteroidetes
Prevotella melaninogenica et rel.
5.6
No
Prevotella oralis et rel.
5.7
No
Firmicutes/Clostridium cl. IV
Clostridium leptum et rel.
2.5
Yes
Oscillospira guillermondii et rel.
4.8
Yes
Sporobacter termitidis et rel.
2.7
Yes
Anaerotruncus colihominis et rel.
3.4
Yes
Ruminococcus callidus et rel.
4.1
Yes
Ruminococcus lactaris et rel.
15.4
No
Ruminococcus bromii et rel.
12.0
Yes
Subdoligranulum variabile et rel.
7.9
No
Firmicutes/Clostridium cl. IX
Dialister spp.
3.6
Yes
Firmicutes/Clostridium cl. XIVa
Lachnospira pectinoschiza et rel.
2.3
Yes
Ruminococcus lactaris et rel.
15.4
No
Butyrivibrio crossotus et rel.
2.5
No
Clostridium colinum et rel.
3.3
Yes
Uncult. Clostridiales
Uncult. ClostridialesI
10.2
Yes
Proteobacteria
Oxalobacter formigenes
3.5
Yes
Phylum/cluster
Decreased bacterial groups in colonic
Fold-change B0 to B1
Decreased in feces F14 m and F2 w–7
Bacteroidetes
Alistipes et rel.
2.0
No
Bacteroides stercoris et rel.
2.4
No
Bacteroides vulgatus et rel.
9.6
Yes
Bacteroides fragilis et rel.
2.1
Yes
Bacteroides ovatus et rel.
3.4
Yes
Bacteroides intestinalis et rel.
3.4
No
Bacteroides plebeius et rel.
2.5
No
Prevotella tannerae et rel.
6.2
Yes
Tannerella et rel.
2.4
No
Parabacteroides distasonis et rel.
4.0
No
Uncult. Bacteroidetes
5.9
No
Firmicutes/Clostridium cl. I
Clostridia
5.8
No
Firmicutes/Clostridium cl. XIVa
Coprococcus eutactus et rel.
2.4
No
Dorea formicigenerans et rel.
4.0
No
Eubacterium rectale et rel.
2.0
No
Ruminococcus gnavus et rel.
7.0
No
Ruminococcus obeum et rel.
4.4
No
Clostridium nexile et rel.
5.3
No
Outgr. Clostridium cl. XIVa
6.2
No
Firmicutes/Clostridium cl. IX
Veillonella spp.
2.7
No
Megasphaera elsdenii et rel.
3.4
No
Firmicutes/Clostridium cl. XI
Clostridium difficile et rel.
23.1
No
Firmicutes/Clostridium cl. XVI
Bulleidia moorei et rel.
2.1
No
Eubacterium cylindroides et rel.
2.2
No
Firmicutes/Clostridium cl. XVIII
Clostridium ramosum et rel.
8.1
Yes
Firmicutes/Bacilli
Streptococcus bovis et rel.
2.3
No
Streptococcus intermedius et rel.
2.3
No
Streptococcus mitis et rel.
2.1
No
Proteobacteria
Sutterella wadsworthia et rel.
2.7
No
Escherichia coli et rel.
3.7
No
Klebsiella pneumonia et rel.
2.2
No
Higher abundance also in the donor’s feces as compared to the patient’s pre-FMT feces; 2lower abundance also in the donor’s feces as compared to the patient’s pre-FMT feces, with the exception of C. eutactus et rel., E. rectale et rel., and S. bovis et rel.; 3increased/decreased abundance in 14 mo and in 2 w to 7 mo (average) post-FMT samples as compared to the pre-FMT fecal sample; Uncult.: uncultured; cl.: cluster; Outgr.: outgrouping.
