Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2014, Article ID 964082, 5 pages
http://dx.doi.org/10.1155/2014/964082
Case Report

Bortezomib Induced Hepatitis B Reactivation

1Department of Internal Medicine, Providence Hospital and Medical Centers, 16001 W 9 Mile Road, Southfield, MI 48075, USA
2Division of Nephrology, Department of Medicine, Providence Hospital and Medical Centers, 16001 W 9 Mile Road, Southfield, MI 48075, USA
3Division of Hematology & Oncology, Department of Medicine, Providence Hospital and Medical Centers, 16001 W 9 Mile Road, Southfield, MI 48075, USA
4Division of Gastroenterology, Department of Medicine, Henry Ford Health System, Detroit, MI 48202, USA

Received 14 March 2014; Revised 12 April 2014; Accepted 13 April 2014; Published 4 May 2014

Academic Editor: Gianfranco D. Alpini

Copyright © 2014 Salwa Hussain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. It has recently been reported that hepatitis B (HBV) reactivation often occurs after the use of rituximab and stem cell transplantation in patients with lymphoma who are hepatitis B surface antigen (HBsAg) negative. However, clinical data on HBV reactivation in multiple myeloma (MM) is limited to only a few reported cases. Bortezomib and lenalidomide have remarkable activity in MM with manageable toxicity profiles, but reactivation of viral infections may emerge as a problem. We present a case of MM that developed HBV reactivation after bortezomib and lenalidomide therapy. Case Report. A 73-year-old female with a history of marginal cell lymphoma was monitored without requiring therapy. In 2009, she developed MM, presenting as a plasmacytoma requiring vertebral decompression and focal radiation. While receiving radiation she developed renal failure and was started on bortezomib and liposomal doxorubicin. After a transient response to 5 cycles, treatment was switched to lenalidomide. Preceding therapy initiation, her serology indicated resolved infection. Serial monitoring for HBV displayed seroconversion one month after change in therapy. Conclusion. Bortezomib associated late HBV reactivation appears to be a unique event that requires further confirmation and brings to discussion whether hepatitis B core positive individuals would benefit from monitoring of HBV activation while on therapy.