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Case Reports in Medicine
Volume 2015, Article ID 232915, 4 pages
Case Report

Isolated Central Nervous System Relapse in Chronic Myeloid Leukemia

1Internal Medicine Department, Guillermo Almenara Irigoyen National Hospital, Grau Avenue 800, Lima, Peru
2National Institute of Neurologic Sciences, Ancash Street 1271, Barrios Altos, Lima, Peru

Received 23 October 2014; Revised 8 March 2015; Accepted 9 March 2015

Academic Editor: Lothar Bergmann

Copyright © 2015 Juliana Gomez and Victor Duenas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic myeloid leukemia is a myeloproliferative disorder that has three distinguished phases: chronic, accelerated, and blastic. In extremely rare cases, the blast phase can affect the central nervous system without concomitant bone marrow involvement. We report the case of a patient with chronic myeloid leukemia who, despite having achieved complete cytogenetic remission in the bone marrow for several years, experienced a blast crisis of the central nervous system following an episode of infectious meningoencephalitis.