Parkinsonism and Sjögren’s Syndrome: A Fortuitous Association or a Shared Immunopathogenesis?

Table 1

Cases of primary SS associated with Parkinsonism reported in the literature.

Authors	Sex/age	Diagnosis of SS before Parkinsonism	Initial clinical symptoms	MRI findings	Treatment	Development
Visser et al. [3]	F/55	No	Left hemiparkinsonian syndrome	Hyperintensities T2 in striatum and pallidum	Corticosteroids; Azathioprine	No improvement
Nagao et al. [4]	F/79	No	Akineto rigide syndrome	Cortical atrophy and cortical hyper-T2 intensity	Levodopa; Corticosteroids	No improvement; Partial improvement
Creange et al. [5]	F/44	Unspecified	Postural instability	Hyper-T2 intensity of white matter	Corticosteroids; Immunoglobulin	Transitory improvement
Mochizuki et al. [6]	H/50	No	Meningitis, akineto-rigide syndrome	Hyper-T2 intensity of white matter	Corticosteroids	Partial improvement
Walker et al. [7]	F/76	Yes	Akineto-rigide syndrome, cognitive disorders	Hyper-T2 intensity of white matter	Without corticosteroids; Methotrexate	No improvement
Walker et al. [7]	F/63	Yes	Postural instability	Normal	Levodopa; Corticosteroids	No improvement
Walker et al. [7]	F/53	No	Parkinsonian tremo akinéto rigide syndrome	Normal	Without treatment	No improvement
Nishimura et al. [8]	F/74	Yes	Postural instability	Diffuse hyper-T2 intensity
Jafoui et al. [9]	F/39	No	Right hemiparkinsonian syndrome	Normal	Levodopa, bromocriptine; Corticosteroids	No improvement; Improvement
Gaundong Mbethe et al. [10]	F/67	No	Parkinsonian tremo akinéto rigide syndrome; Headaches	Hyper-T2 intensity of white matter	Corticosteroids; Cyclophosphamide	Improvement of tremor
Essaadouni et al. [11]	F/66	No	Akinéto-rigide syndrome	Frontal ischemic gaps and lenticular nuclei	Levodopa; Piribedil	No improvement
					Corticosteroids	Improvement
Our case	F/46	No	Parkinsonian tremo akinéto rigide syndrome	Normal	Levodopa; Corticosteroids	Partial improvement; Improvement