Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2015, Article ID 606805, 4 pages
http://dx.doi.org/10.1155/2015/606805
Case Report

Pulmonary Embolism in a Sarcoidosis Patient Double Heterozygous for Methylenetetrahydrofolate Reductase Gene Polymorphisms and Factor V Leiden and Homozygous for the D-Allele of Angiotensin Converting Enzyme Gene

1Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110 72020, Lebanon
2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut 110 72020, Lebanon

Received 1 March 2015; Accepted 28 July 2015

Academic Editor: Christian Koch

Copyright © 2015 Nadim El-Majzoub et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. G. Scadding, “Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation,” British Medical Journal, vol. 2, no. 5261, pp. 1165–1172, 1961. View at Publisher · View at Google Scholar
  2. I. H. Ortega and L. L. González, “Thoracic sarcoidosis,” Radiologia, vol. 53, no. 5, pp. 434–448, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. P. Crawshaw, C. J. Wotton, D. G. R. Yeates, M. J. Goldacre, and L.-P. Ho, “Evidence for association between sarcoidosis and pulmonary embolism from 35-year record linkage study,” Thorax, vol. 66, no. 5, pp. 447–448, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Taher, I. Khalil, A. Shamseddine, F. El-Ahdab, and A. Bazarbachi, “High prevalence of factor V leiden mutation among healthy individuals and patients with deep venous thrombosis in Lebanon: is the eastern Mediterranean region the area of origin of this mutation?” Thrombosis and Haemostasis, vol. 86, no. 2, pp. 723–724, 2001. View at Google Scholar · View at Scopus
  5. P. A. Zalloua, H. Shbaklo, Y. A. Mourad, S. Koussa, and A. Taher, “Incidence of thromboembolic events in Lebanese thalassemia intermedia patients,” Thrombosis and Haemostasis, vol. 89, no. 4, pp. 767–768, 2003. View at Google Scholar · View at Scopus
  6. W. Y. Almawi, R. R. Finan, H. Tamim, J. L. Daccache, and N. Irani-Hakime, “Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population,” The American Journal of Hematology, vol. 76, no. 1, pp. 85–87, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. B. S. Erdal, B. D. Clymer, V. O. Yildiz, M. W. Julian, and E. D. Crouser, “Unexpectedly high prevalence of sarcoidosis in a representative U.S. Metropolitan population,” Respiratory Medicine, vol. 106, no. 6, pp. 893–899, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. T. H. Al-Khouzaie, J. A. Al-Tawfiq, and F. M. Al Subhi, “Sarcoidosis in the eastern region of Saudi Arabia,” Annals of Thoracic Medicine, vol. 6, no. 1, pp. 22–24, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Musellim, O. O. Kumbasar, G. Ongen et al., “Epidemiological features of Turkish patients with sarcoidosis,” Respiratory Medicine, vol. 103, no. 6, pp. 907–912, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. J. Swigris, A. L. Olson, T. J. Huie et al., “Increased risk of pulmonary embolism among US decedents with sarcoidosis from 1988 to 2007,” Chest, vol. 140, no. 5, pp. 1261–1266, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Simone, V. De Stefano, E. Leoncini et al., “Risk of venous thromboembolism associated with single and combined effects of Factor v Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls,” European Journal of Epidemiology, vol. 28, no. 8, pp. 621–647, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. T. J. Rebeiz, R. Mahfouz, A. Taher, K. Charafeddine, and N. Kanj, “Unusual presentation of a sarcoid patient: multiple arterial and venous thrombosis with chest lymphadenopathy,” Journal of Thrombosis and Thrombolysis, vol. 28, no. 2, pp. 245–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Ungprasert and N. Srivali, “Is sarcoidosis a thrombophilic disorder?” Annals of Hematology, vol. 92, no. 12, pp. 1721–1722, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Chen, S. Dong, M. He, T. Qi, and W. Zhu, “Angiotensin-converting enzyme insertion/deletion polymorphism and risk of myocardial infarction in an updated meta-analysis based on 34993 participants,” Gene, vol. 522, no. 2, pp. 196–205, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Yilmaz, M. Karkucak, F. Coşkun, T. Yakut, and E. K. Uzaslan, “ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients,” Tüberküloz ve Toraks, vol. 60, no. 3, pp. 201–206, 2012. View at Google Scholar · View at Scopus