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Case Reports in Medicine
Volume 2015, Article ID 769576, 3 pages
Case Report

Neuroleptic Malignant Syndrome: A Case Aimed at Raising Clinical Awareness

Department of Internal Medicine, Thomas Jefferson University Hospital, 1025 Walnut Street, Jefferson College Building, Suite 805, Philadelphia, PA 19107, USA

Received 2 May 2015; Revised 4 June 2015; Accepted 7 June 2015

Academic Editor: Paul Dargan

Copyright © 2015 Jad Al Danaf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 60-year-old man with a history of bipolar disorder on risperidone, bupropion, and escitalopram was admitted for community acquired streptococcal pneumonia. Four days later, he developed persistent hyperthermia, dysautonomia, rigidity, hyporeflexia, and marked elevation of serum creatine phosphokinase. He was diagnosed with neuroleptic malignant syndrome (NMS) and improved with dantrolene, bromocriptine, and supportive therapy. This case emphasizes the importance of considering a broad differential diagnosis for fever in the ICU, carefully reviewing the medication list for all patients, and considering NMS in patients with fever and rigidity.