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Case Reports in Medicine
Volume 2016, Article ID 2407607, 4 pages
Case Report

Hyperemesis Gravidarum in Undiagnosed Gitelman’s Syndrome

Department of Medicine, University of South Alabama, Mobile, AL 36617, USA

Received 25 May 2016; Accepted 5 July 2016

Academic Editor: Raoul Orvieto

Copyright © 2016 Maria Czarina Acelajado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Gitelman’s syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the renal distal convoluted tubule. Physiologic changes of pregnancy promote renal potassium wasting, but serum potassium levels are kept in the physiologic range by increased levels of progesterone, which resist kaliuresis. In the presence of GS, this compensatory mechanism is easily overwhelmed, resulting in profound hypokalemia. We present a case of an 18-year-old primigravida with undiagnosed GS who presented with hyperemesis gravidarum in her 7th week of pregnancy. This report adds to the limited experience with GS in pregnancy as reported in literature and provides additional information on medical management that leads to successful maternal and fetal outcomes.