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Case Reports in Medicine
Volume 2016, Article ID 3015947, 5 pages
Case Report

Heralding Extramedullary Blast Crisis: Horner’s Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia

1Memphis Neurology, 1407 Union Avenue, No. 1400, Memphis, TN 38014, USA
2Baptist Cancer Center, 6029 Walnut Grove Rd, No. 300, Memphis, TN 38120, USA

Received 18 September 2016; Accepted 1 December 2016

Academic Editor: Thomas R. Chauncey

Copyright © 2016 Sajish Jacob and Sadanand I. Patil. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic myelogenous leukemia (CML) blast crisis is an ominous clinical event that is challenging to treat. This can develop at extramedullary sites rarely and is defined as the infiltration of blasts outside the bone marrow irrespective of proliferation of blasts within the bone marrow. We aim to report an unusual clinical presentation characterized by Horner’s syndrome, ipsilateral arm weakness, and cervical lymphadenopathy as the first signs of extramedullary blast crisis in a CML patient. To the best of our knowledge, the extramedullary locations involving the brachial plexus along with cervicothoracic paraspinal chloroma have not been previously reported in the literature.