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Case Reports in Medicine
Volume 2016, Article ID 5134546, 3 pages
Case Report

Sacroiliitis and Polyarteritis Nodosa in a Patient with Familial Mediterranean Fever

1Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Suleyman Demirel University, 32260 Isparta, Turkey
2Faculty of Medicine, Department of Internal Medicine, Suleyman Demirel University, 32260 Isparta, Turkey

Received 3 February 2016; Revised 11 March 2016; Accepted 14 March 2016

Academic Editor: Mamede de Carvalho

Copyright © 2016 Yunus Ugan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Familial Mediterranean fever (FMF) is an autoinflammatory disorder with autosomal recessive inheritance, characterized by recurrent fever and episodes of serositis. The condition is known to be caused by mutations in the MEFV (Mediterranean FeVer) gene, located in the short arm of chromosome 16. While more than 310 sequence variants in the MEFV gene have been described to date, the diagnosis is still established clinically. FMF may be accompanied by sacroiliitis and various forms of vasculitis. The most common forms of associated vasculitis are Henoch-Schonlein purpura and polyarteritis nodosa (PAN). We have presented here a fairly rare case of FMF, accompanied by both sacroiliitis and PAN.