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Case Reports in Medicine
Volume 2016, Article ID 5434230, 4 pages
Case Report

Severe Hyponatremia due to Levofloxacin Treatment for Pseudomonas aeruginosa Community-Acquired Pneumonia in a Patient with Oropharyngeal Cancer

1Department of Internal Medicine, University of Medicine and Pharmacy, Cluj-Napoca, Romania
21st Medical Clinic, County Emergency Hospital, Cluj-Napoca, Romania

Received 16 August 2016; Accepted 5 October 2016

Academic Editor: Florian Thalhammer

Copyright © 2016 Mihaela Mocan and Sorin Nicu Blaga. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hyponatremia (serum Na levels of <135 mEq/L) is the most common electrolyte imbalance encountered in clinical practice, affecting up to 15–28% of hospitalized patients. This case report refers to a middle-aged man with severe hyponatremia due to Syndrome of Inappropriate Antidiuretic Hormone Secretion related to four possible etiological factors: glossopharyngeal squamous cell carcinoma, cisplatin treatment, right basal pneumonia with Pseudomonas aeruginosa, and the treatment with Levofloxacin. This case report discusses a rare complication of common conditions and of a common treatment. To our knowledge this is the first case of hyponatremia related to Levofloxacin and the second related to fluoroquinolones.