Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature

<div>Myeloid neoplasm with t(5;12) and ETV6-ACSL6 gene fusion: morphologic and cytogenetic features. (a) Peripheral blood with a predominant population of eosinophil precursors: large cells with mononuclear, monolobated nuclei and abundant cytoplasm containing eosinophilic granules. The predominant cell type is eosinophil myelocyte, but there is a spectrum of forms including eosinophil metamyelocytes, eosinophils bands, and mature eosinophils. Promyelocytes and myeloblasts are not observed (Wright stain, 1000x). (b) Bone marrow biopsy showing replacement of the marrow space by sheets of eosinophils and eosinophil precursors (hematoxylin and eosin, 500x). (c) Partial karyogram demonstrating t(5;12)(q31;p13) that was identified in 17 out of 20 cells cultured.</div>

Case Reports in Medicine

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Figure 1: Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature 

Figure 1 | Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature 