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Case Reports in Medicine
Volume 2017, Article ID 7892980, 4 pages
Case Report

Intraplacental Choriocarcinoma: Rare or Underdiagnosed? Report of 2 Cases Diagnosed after an Incomplete Miscarriage and a Preterm Spontaneous Vaginal Delivery

1Department of Obstetrics and Gynecology, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal
2Department of Anatomic Pathology Lab Albino Oliveira, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal
3Department of Anatomic, Cytopathology and Thanatology, Escola Superior de Saúde, Instituto Politécnico do Porto, Porto, Portugal
4Department of Fetal Pathology and Anatomic Pathology Lab, CGC Genetics, Porto, Portugal
5Life and Health Sciences Research Institute (ICVS), School of Medicine, ICVS/3B’s-PT Government Associate Laboratory, Campus of Gualtar, University of Minho, Guimarães, Braga, Portugal

Correspondence should be addressed to Rita Ferraz Caldas; moc.liamg@sadlacfatir

Received 19 January 2017; Accepted 15 March 2017; Published 16 April 2017

Academic Editor: Raoul Orvieto

Copyright © 2017 Rita Ferraz Caldas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intraplacental choriocarcinoma is a rare malignant tumor diagnosed after an abortion, an ectopic pregnancy, or a term or preterm pregnancy or following the diagnosis of a hydatidiform mole. During pregnancy, it may be more common than reported, as most patients are asymptomatic and placental choriocarcinomas are usually inconspicuous macroscopically and are often mistaken for an infarct. Based upon a case study methodology, we describe 2 cases of intraplacental choriocarcinoma: the first case was identified in the product of a uterine curettage following an incomplete miscarriage and the second in one of the placentas of a bichorionic twin pregnancy. Maternal investigation did not reveal evidence of metastatic disease and neither did the infants’ one in the second case. The two cases underwent maternal surveillance with serum hCG and remained disease-free until the present. In conclusion, intraplacental choriocarcinoma is easily underdiagnosed but with current treatment, even in the presence of metastasis, the prognosis is excellent. A routine microscopic examination of all the placentas and products of miscarriage can increase the real incidence of this entity and consequently improve its management.