Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Medicine
Volume 2018 (2018), Article ID 1230285, 5 pages
Case Report

Gastric Schwannoma: A Case Report and Review of the Literature for Gastric Submucosal Masses Distinction

1Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
2Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Oncology, Seyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
4Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
5Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence should be addressed to Amirhosein Kefayat; moc.oohay@tayafekha

Received 1 December 2017; Revised 3 February 2018; Accepted 7 March 2018; Published 10 April 2018

Academic Editor: Isidro Machado

Copyright © 2018 Behnam Sanei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Schwannomas origin from Schwann cells sheath and generally are benign, slow-growing, and asymptomatic neoplasms which frequently appear in the head and neck. Although gastrointestinal schwannoma is really rare, the most affected organ in GI system is the stomach. Gastric schwannoma forms 0.2% of all gastric tumors. This neoplasm is always detected as a submucosal mass, the same as other gastrointestinal stromal tumors. Although these tumors have almost the same presentations, they are completely different at therapeutic options and prognoses. Hence, it is important to distinguish them apart and make an accurate diagnosis to optimize treatment outcomes. Herein, we report a case of 28-year-old woman with frequent vomiting and abdominal pain caused by 5 × 6 cm schwannoma in the antrum of the stomach. This is a rare case of gastric outlet obstruction due to a massive schwannoma. In addition, all other probable submucosal masses will be discussed at different aspects.

1. Introduction

Submucosal tumors (SMTs) include a wide spectrum of benign-to-malignant lesions. SMT employs to define the intramural neoplasms underneath the mucosa. The incidence of SMTs in the whole gastrointestinal (GI) tract is unknown. However, the stomach is frequently the most affected organ [1]. Gastric SMTs are divided into three major categories according to the ultrastructural characteristics and protein marker profiles including myogenic tumors, neurogenic tumors, and gastrointestinal stromal tumors (GISTs) [2]. Theses lesions are usually asymptomatic and incidentally diagnosed during various diagnostic procedures. When the physician encounters such lesions, it is necessary to distinguish them from each other for choosing the appropriate therapeutic option.

In this case report, a 28-year-old woman with a 5 × 6 cm mass in the antrum of the stomach will be presented. She was complaining of frequent vomiting (sometimes bloody) and abdominal pain. After the surgery, the complaints were relieved and histopathological and immunohistochemistry assessments revealed a gastric schwannoma. In addition, other SMTs, as differential diagnoses, will be discussed at different aspects.

2. Case Presentation

A 28-years-old woman was admitted to our emergency department due to abdominal pain, recurrent vomiting, and hematemesis. The patient had been suffering from abdominal pain for several weeks, and the symptoms gradually have worsened until the time of admission when she had severe anorexia and recurrent vomiting. She did not have any systemic and local complication, and the physical examinations did not reveal anything special. After the admission, the patient underwent diagnostic endoscopic study which showed a 5 cm × 6 cm antral submucosal mass with central umbilication. The mass was causing gastric outlet obstruction. Double contrast-enhanced abdominopelvic CT scan was performed and revealed a hypodense mass along the anterior wall of the gastric antrum with subsequent pyloric stenosis and luminal obstruction with gastric dilatation in the body and fundus (Figure 1). Possible GIST was suggested, and the patient was consulted for the surgery. The open surgery for the obstruction relief was done, and subtotal gastrectomy with Roux-en-Y gastrojejunostomy was successfully performed (Figure 2).

Figure 1: Abdominopelvic CT scan with IV and oral contrast. A 5 cm × 6 cm soft, hypodense mass along the anterior wall of the gastric antrum with subsequent pyloric stenosis and luminal obstruction with gastric dilatation in the body and fundus (the red arrow indicates the mass).
Figure 2: Resected gastric mass after surgery.

Pathological examinations were done, and characteristic histological findings for gastric schwannoma were detected (Figure 3). The tumoral capsule which encompassed wavy spindled cells separated by fibrotic bundles woven together in various directions was observed. In addition, lymphoid aggregations around the capsule were apparent. Surgical margins were free, and 3 reactive lymph nodes were seen. Subsequent immunohistochemical staining was performed, and the tumor cells were negative for CD117, CD34, KI67, actin, chromogranin, and desmin. However, they were positive for S100 protein diffusely at nucleus and cytoplasm. Based on histology and immunohistochemistry findings, the final diagnosis of gastric submucosal schwannoma was considered.

Figure 3: Histopathological and immunohistochemical examinations. (a) Wavy spindled cells separated by woven fibrotic bundles which encompassed by the capsule (black arrow) are apparent. Also, the tumor capsule is surrounded by lymphoid follicles (white arrow). (b) High-power field view. (c) S100 protein is apparent at tumoral parts with diffuse staining as a characteristic feature for schwannoma.

3. Discussion

The SMTs are divided into three major categories including myogenic tumors (leiomyomas or leiomyosarcomas), neurogenic tumors (schwannomas, granular cell tumors, and neurofibromas), and GISTs [3].

Gastrointestinal neurogenics derive from different components of nerve fibers, mostly autonomic components of Auerbach’s plexus [4]. They consist 5% of nonepithelial gastric tumors and are mostly benign with 10% malignant transformation risk [5, 6]. Schwannoma, neurofibroma, and granular cell tumors are their subtypes. Schwannomas consist about 91% of the neurogenic tumors [7]. Neurofibroma is associated with the von Recklinghausen’s disease. Therefore, the GI tract-related nerve sheath neoplasms mostly are detected at neurofibromatosis patients with apparent systemic manifestations like café au lait spots. Isolated GI neurofibroma without any associated systemic syndrome is an extremely rare clinical entity and forms 0.1% of all gastric neoplasms and frequently has been discovered in the small intestine [8]. Schwannomas arise from Schwann cells sheath. They are generally benign, slow-growing, and asymptomatic neoplasms which commonly occur in the head and neck. However, the GI involvement is really rare. The most common site for GI schwannomas is the stomach representing 0.2% of all gastric tumors, and malignant transformation risk is low [911]. Granular cell tumors (GCTs) are extremely rare neoplasm.

Myogenic tumors include leiomyomas and leiomyosarcomas which are rare and can be found anywhere along the GI tract. However, they are more common in the esophagus, stomach, and colon and arise in muscularis mucosae or muscularis propria [12].

GIST is the most common kind of submucosal mesenchymal neoplasms of the GI tract. The incidence of GISTs is 10–20 per million and the stomach is the most common location. Approximately 60% to 70% of GISTs arise in this organ and form 0.1%–3.0% of all GI malignant tumors [13, 14]. GISTs arise from Cajal cells which are the smooth muscles pacemaker cells in the GI tract. KIT gene mutation is the main factor for development of GISTs as 85% cases are positive for this mutation [15, 16]. Therefore, GIST’s definition, diagnosis, and treatment are dependent on this mutation. Due to remarkable response of GISTs to the imatinib treatment as a molecular inhibitor of c-Kit, its accurate diagnosis from other gastrointestinal SMTs is vital [16].

Gastric SMTs frequently are so small and noninvasive to become symptomatic. According to a report by Perea and Gregory, abdominal pain is the most common symptom. GI bleeding, anemia, epigastric mass, nausea, and vomiting can also occur. Dyspeptic symptoms, anorexia, and epigastric tenderness are among rare symptoms [2, 17]. About 10–30% of GISTs are completely asymptomatic. Usually big GISTs, more than 6 cm in diameter, can cause symptoms, and the most common presentation is abdominal pain and/or GI bleeding [18, 19]. The upper GI bleeding has been named as the most common symptom for symptomatic schwannoma [20, 21].

It is obvious that clinical symptoms are nonspecific, and distinction of gastric submucosal masses with clinical presentation is approximately impossible. The standard procedures for establishing diagnoses in patients with GI tumors are endoscopic mucosal forceps biopsy. However, its false negative rate can be as high as 50%. Therefore, the endoscopic ultrasound (EUS) and EUS-guided biopsy (EUS-B) would be helpful as the most accurate procedures for definite diagnosis of GI tumors with negative endoscopic biopsies. EUS shows typical findings for some lesions, but in hypoechoic lesions, such as leiomyomas, GISTs, and schwannomas, EUS findings are not enough and EUS-Bs are needed. Due to deeper location than epithelium, biopsies cannot be taken from the subepithelial lesions by conventional endoscopic methods, and EUS-B should be employed [22, 23].

Also, imaging techniques are needed and computed tomography (CT) is a more common diagnostic tool for these cases. The CT scan presentation of GISTs depends on its size, aggressiveness, and the course of the disease. Primary GISTs are mostly large hypervascular lesions which exhibit as enhancing masses at contrast-enhanced CT scans with heterogeneous presentations due to necrosis, hemorrhage, or cystic degeneration [24, 25]. In comparison with GISTs, gastric schwannomas more frequently exhibit a homogeneous enhancement, exophytic, or mixed growth pattern with cystic degenerations. Due to overlapping properties at imaging, it is impossible to distinguish GIST and leiomyomas from each other with imaging modalities. Therefore, the final diagnosis is established by immunohistochemical examination [2628]. Gastric neurofibromas at CT scan exhibit hypoattenuated mass lesion with usually well-defined borders. Tumor can be intramural or extramural, and central calcification is probable. Regardless of the origin, it will exhibit heterogeneous enhancement after contrast administration. Hemorrhage or necrosis occur at giant masses and will be detected as low-density component. These changes plus size and attenuation asymmetry can be predictive factors for malignant transformation [29, 30].

Although imaging techniques are helpful, histopathological analyses should be established to confirm the diagnosis [31]. The neurofibroma is usually described as nonencapsulated tumors consisting of Schwann cells, endoneurial fibroblasts, and perineurial-like cells in a context of mucinous matrix with wavy fibrotic collagenous bundles which are surrounded with mast cells infiltrations [32]. GI schwannomas are capsulated tumors consisting of spindle cells with prominent lymphoid aggregations which are characterized by Antoni A and Antoni B areas, and the absence of typical Verocay bodies [33, 34]. 70% of all GISTs contain spindle-shaped cell, and 20% are of epithelioid type at the histopathology. However, they also can be pleomorphic [35]. Leiomyomas, the same as the GIST, are of spindle-shaped cells. Therefore, their distinction just can be confirmed by immunohistochemistry examinations [36].

Immunohistochemical analysis should be done to approve the probable diagnoses in all SMTs. GISTs are mostly considered CD117-positive, generally CD34-positive, actin-positive, and S100-negative [19, 31, 37]. In addition, desmin staining can help for distinction between the GISTs with myogenic tumors. Desmin expression is negative at the GIST and positive for the myogenic tumors, while others are the same [38, 39]. Positive staining for S100 protein and vimentin and negative staining for smooth muscle actin, c-KIT, and CD34 supports the notion that the tumor is neurogenic. There are some evidences that schwannomas have a greater extent of S100 with a diffuse pattern expression in comparison with neurofibromas. It is obvious that relying on expression profile of these markers is not sufficient for distinction of these two subtypes of neurogenic tumors. Therefore, new studies introduce calretinin as a helpful diagnostic marker for neurogenic tumor distinguishing from each other [7].

In our case, the tumor cells were negative for CD117, CD34, and actin while were positive for S100. Therefore, GIST and myogenic tumors were excluded, and histological pattern of lymphoid aggregation plus capsule presence highly suggested schwannoma rather than neurofibroma.

This case was operated due to relief of obstruction symptoms with a probable diagnosis of GIST. In the course of surgery due to the presence of the 5 cm × 6 cm mass in the lesser curvature of gastric antrum and to obtain a 2 cm safety margin for the mass resection, subtotal gastrectomy was evitable. The lesser curvature masses resection causes vague nerve eradication and subsequent pylorus dysfunction. Therefore, for the lesser curvature masses, subtotal gastrectomy is the choice plan. In addition, subtotal gastrectomy is the treatment of choice for middle- and distal-third gastric neoplasm [40]. Therefore, the open surgery for subtotal gastrectomy and Roux-en-Y gastrojejunostomy was done. The definitive diagnosis of schwannoma was determined through postoperative pathological assessment.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Authors’ Contributions

Amirhosein Kefayat, Melika Samadi, and Parvin Goli wrote the case presentation. Behnam Sanei, Mohammad Hossein Sanei, and Mahsa Khodadustan performed the patient diagnosis and treatment. Behnam Sanei did the surgical procedure, and Mohammad Hossein Sanei did pathological examinations. Amirhosein Kefayat and Behnam Sanei supervised the study and wrote the literatures’ review for submucosal masses distinction.


The authors appreciate Zahra Valiniya for graphic editing of the manuscript picture.


  1. J. L. Hedenbro, M. Ekelund, and P. Wetterberg, “Endoscopic diagnosis of submucosal gastric lesions. The results after routine endoscopy,” Surgical Endoscopy, vol. 5, no. 1, pp. 20–23, 1991. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Al-Harake, M. Chour, and O. S. Al Beteddini, “Solitary intestinal neurofibroma with no associated systemic syndromes causing intussusception: case report and literature review,” International Journal of Surgery Case Reports, vol. 4, no. 7, pp. 629–632, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Nishida and S. Hirota, “Biological and clinical review of stromal tumors in the gastrointestinal tract,” Histology and Histopathology, vol. 15, no. 4, pp. 1293–1301, 2000. View at Google Scholar
  4. N. M. Walsh and A. Bodurtha, “Auerbach’s myenteric plexus. A possible site of origin for gastrointestinal stromal tumors in von Recklinghausen’s neurofibromatosis,” Archives of Pathology & Laboratory Medicine, vol. 114, no. 5, pp. 522–525, 1990. View at Google Scholar
  5. A. Madro, W. Kosikowski, J. Drabko et al., “Neurofibroma of the stomach without Recklinghausen’s disease: a case report,” Gastroenterology Review, vol. 5, pp. 310–312, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. J. N. Bruneton, J. Drouillard, P. Roux, F. Ettore, and P. Lecomte, “Neurogenic tumors of the stomach. Report of 18 cases and review of the literature,” RöFo-Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, vol. 139, no. 2, pp. 192–198, 1983. View at Publisher · View at Google Scholar
  7. R. T. Miller, Immunohistochemistry in the Differential Diagnosis of Schwannoma and Neurofibroma, Propath Services, Dallas, TX, USA, 2004.
  8. J. R. Bakker, M. M. Haber, and F. U. Garcia, “Gastrointestinal neurofibromatosis: an unusual cause of gastric outlet obstruction,” American Surgeon, vol. 71, no. 2, pp. 100–105, 2005. View at Google Scholar
  9. M. Sarlomo-Rikala and M. Miettinen, “Gastric schwannoma—a clinicopathological analysis of six cases,” Histopathology, vol. 27, no. 4, pp. 355–360, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Yoon, K. Paulson, P. Mazzara, S. Nagori, M. Barawi, and R. Berri, “Gastric schwannoma: a rare but important differential diagnosis of a gastric submucosal mass,” Case Reports in Surgery, vol. 2012, Article ID 280982, 5 pages, 2012. View at Publisher · View at Google Scholar
  11. A. Singh, A. Mittal, B. Garg, and N. Sood, “Schwannoma of the stomach: a case report,” Journal of Medical Case Reports, vol. 10, no. 1, pp. 1–3, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Miettinen, M. Sarlomo-Rikala, and L. H. Sobin, “Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors–a clinicopathologic and immunohistochemical study of eighty-eight cases,” Modern Pathology, vol. 14, no. 10, pp. 950–956, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Miettinen and J. Lasota, “Gastrointestinal stromal tumors–definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis,” Virchows Archiv, vol. 438, no. 1, pp. 1–12, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. K. M. Kim, D. W. Kang, W. S. Moon et al., “Gastrointestinal stromal tumors in Koreans: it’s incidence and the clinical, pathologic and immunohistochemical findings,” Journal of Korean Medical Science, vol. 20, no. 6, pp. 977–984, 2005. View at Publisher · View at Google Scholar
  15. M. Miettinen and J. Lasota, “Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics,” Polish Journal of Pathology, vol. 54, no. 1, pp. 3–24, 2003. View at Google Scholar
  16. A. Rammohan, J. Sathyanesan, K. Rajendran et al., “A gist of gastrointestinal stromal tumors: a review,” World Journal of Gastrointestinal Oncology, vol. 5, no. 6, pp. 102–112, 2013. View at Publisher · View at Google Scholar
  17. V. D. Perea and L. J. Gregory, “Neurofibromatosis of the stomach: report of a case associated with von recklinghausen’s disease and review of the literature,” Journal of the American Medical Association, vol. 182, no. 3, pp. 259–263, 1962. View at Publisher · View at Google Scholar · View at Scopus
  18. C. B. Tan, W. Zhi, G. Shahzad, and P. Mustacchia, “Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directions,” ISRN Gastroenterology, vol. 2012, Article ID 595968, 16 pages, 2012. View at Publisher · View at Google Scholar
  19. H. Cichoz-Lach, B. Kasztelan-Szczerbinska, and M. Slomka, “Gastrointestinal stromal tumors: epidemiology, clinical picture, diagnosis, prognosis and treatment,” Polskie Archiwum Medycyny Wewnętrznej, vol. 118, no. 4, pp. 216–221, 2008. View at Google Scholar
  20. Y. Fujii, N. Taniguchi, Y. Hosoya et al., “Gastric schwannoma sonographic findings,” Journal of Ultrasound in Medicine, vol. 23, no. 11, pp. 1527–1530, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. W. S. Melvin and M. G. Wilkinson, “Gastric schwannoma. Clinical and pathologic considerations,” American Surgeon, vol. 59, no. 5, pp. 293–296, 1993. View at Google Scholar
  22. H. H. Okasha, M. Naguib, M. El Nady et al., “Role of endoscopic ultrasound and endoscopic-ultrasound-guided fine-needle aspiration in endoscopic biopsy negative gastrointestinal lesions,” Endoscopic Ultrasound, vol. 6, no. 3, p. 156, 2017. View at Publisher · View at Google Scholar · View at Scopus
  23. J. S. Moon, “Endoscopic ultrasound-guided fine needle aspiration in submucosal lesion,” Clinical Endoscopy, vol. 45, no. 2, p. 117, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Hong, H. Choi, E. M. Loyer et al., “Gastrointestinal stromal tumor: role of CT in diagnosis and in response evaluation and surveillance after treatment with imatinib,” Radiographics, vol. 26, no. 2, pp. 481–495, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Werewka-Maczuga, T. Osiński, R. Chrzan, M. Buczek, and A. Urbanik, “Characteristics of computed tomography imaging of gastrointestinal stromal tumor (GIST) and related diagnostic problems,” Polish Journal of Radiology, vol. 76, no. 3, p. 38, 2011. View at Google Scholar
  26. A. D. Levy, A. M. Quiles, M. Miettinen, and L. H. Sobin, “Gastrointestinal schwannomas: CT features with clinicopathologic correlation,” American Journal of Roentgenology, vol. 184, no. 3, pp. 797–802, 2005. View at Publisher · View at Google Scholar
  27. H. S. Hong, H. K. Ha, H. J. Won et al., “Gastric schwannomas: radiological features with endoscopic and pathological correlation,” Clinical Radiology, vol. 63, no. 5, pp. 536–542, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. W. Choi, D. Choi, K. Kim et al., “Small submucosal tumors of the stomach: differentiation of gastric schwannoma from gastrointestinal stromal tumor with CT,” Korean Journal of Radiology, vol. 13, no. 4, pp. 425–433, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. B. J. Fortman, B. S. Kuszyk, B. A. Urban, and E. K. Fishman, “Neurofibromatosis type 1: a diagnostic mimicker at CT,” Radiographics, vol. 21, no. 3, pp. 601–612, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. J. C. Bass, M. Korobkin, I. R. Francis, J. H. Ellis, and R. H. Cohan, “Retroperitoneal plexiform neurofibromas: CT findings,” American Journal of Roentgenology, vol. 163, no. 3, pp. 617–620, 1994. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. W. Ke, D. Chen, J. Cai, and C. Zheng, “Extraluminal laparoscopic wedge-resection of submucosal tumors on the posterior wall of the gastric fundus close to the esophagocardiac junction,” Journal of Laparoendoscopic and Advanced Surgical Techniques, vol. 19, no. 6, pp. 741–744, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Donk, P. Poyck, P. Westenend, W. Lesterhuis, and F. Hesp, “Recurrent abdominal complaints caused by a cecal neurofibroma: a case report,” World Journal of Gastroenterology, vol. 17, no. 34, pp. 3953–3956, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Atmatzidis, G. Chatzimavroudis, D. Dragoumis, P. Tsiaousis, A. Patsas, and K. Atmatzidis, “Gastric schwannoma: a case report and literature review,” Hippokratia, vol. 16, no. 3, pp. 280–282, 2012. View at Google Scholar
  34. Y. Daimaru, H. Kido, H. Hashimoto, and M. Enjoji, “Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study,” Human Pathology, vol. 19, no. 3, pp. 257–264, 1988. View at Publisher · View at Google Scholar · View at Scopus
  35. C. D. Fletcher, J. J. Berman, C. Corless et al., “Diagnosis of gastrointestinal stromal tumors: a consensus approach,” Human Pathology, vol. 33, no. 5, pp. 459–465, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. V. Janevska, A. Qerimi, N. Basheska et al., “Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 12, p. 15977, 2015. View at Google Scholar
  37. S. W. Fine, S. A. McClain, and M. Li, “Immunohistochemical staining for calretinin is useful for differentiating schwannomas from neurofibromas,” American Journal of Clinical Pathology, vol. 122, no. 4, pp. 552–559, 2004. View at Publisher · View at Google Scholar
  38. T. Hasegawa, Y. Matsuno, T. Shimoda, and S. Hirohashi, “Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade,” Human Pathology, vol. 33, no. 6, pp. 669–676, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Debiec-Rychter, B. Wasag, M. Stul et al., “Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity,” Journal of Pathology, vol. 202, no. 4, pp. 430–438, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Santoro, G. M. Ettorre, and E. Santoro, “Subtotal gastrectomy for gastric cancer,” World Journal of Gastroenterology, vol. 20, no. 38, p. 13667, 2014. View at Publisher · View at Google Scholar · View at Scopus