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Author(s) | Age | Sex | Presentation | Cell count | Treatment | Outcome |
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McMahon and Kamath [11] | 25 | F | Known hypothyroidism, iron deficiency anemia, fatigue, weight loss | WBC 3800/µL | Levothyroxine + vitamin B12 | Complete resolution of pancytopenia on 2-month follow-up |
Hemoglobin 6.9 g/dL |
Platelet 158 × 109/L |
Rathi and Peacey [6] | 64 | F | No past medical history, 4-week history of bilateral leg swelling, tiredness, dry skin | WBC 2900/µL | Levothyroxine | Complete resolution of proteinuria and pancytopenia on 3-month follow-up after discharge |
Hemoglobin 10.2 g/dL |
Platelet 127 × 109/L (150–400) |
Tsoukas [4] | 82 | F | Confusion, lethargy, bradycardia, hypothermia, respiratory stridor, no past medical history | WBC 3990/µL | IV hydrocortisone + IV levothyroxine, subsequent PO levothyroxine on discharge | Complete resolution of pancytopenia on 4-week follow-up after discharge |
Hemoglobin 8.5 g/dL, |
Platelet 27 × 109/L |
Song et al. [8] | 68 | F | Increasing immobility over 12 months, alopecia, drowsy, slurred speech, deep voice, no other past medical history | WBC 1600/µL | IV hydrocortisone + IV triiodothyronine, oral levothyroxine replacement 1 week later | Resolution of white cell count and platelet count at 6 weeks on discharge Improved hemoglobin at 4-month follow-up after discharge |
Hemoglobin 8.2 g/dL |
Platelet 35 × 109/L |
Lee AC [5], letter to the editor | 11 | F | Patient developed postablative hypothyroidism and pancytopenia after radiotherapy for suprasellar germinoma | Absolute neutrophil 0 | Packed red blood cell and platelet transfusions, thyroxine replacement + hormonal replacement | Pancytopenia resolved within a week of thyroid hormone replacement |
Hemoglobin 6.9 g/dL |
Platelet 8 × 109/L |
Shaaban et al. [10] | 57 | F | Restlessness, increased fatigue, weight gain, puffy face | WBC 2500/µL | Initially IV and PO levothyroxine, discharged on PO only | White cell count improved after 1 week of thyroid replacement, at 3-month follow-up, her hematologic counts were stable |
Hemoglobin 8.4 g/dL |
Platelet 95 × 109/L |
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