Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI

Table 1

Cases of rhabdomyolysis precipitated by sitagliptin-statin drug interaction.

Reference	Medications	Duration of statin therapy	Duration of sitagliptin therapy	Peak CK level (U/L)	Associated AKI
[4]	Atorvastatin 20 mg + sitagliptin 100 mg	1 year	3 weeks	49,875	Yes
[5]	Atorvastatin 40 mg + sitagliptin 100 mg	Several years	1 week	13,456	No
[6]	Simvastatin 80 mg + sitagliptin 100 mg	4 months	3 weeks	22,000	Yes
[7]	Lovastatin 40 mg + sitagliptin 100 mg	12 years	19 days	3770	No
[8]	Atorvastatin + sitagliptin	5 years	6 months	109,710	No
[9]	Atorvastatin 80 mg + sitagliptin	N/A	N/A	1253	No
Our case	Simvastatin 80 mg + sitagliptin 100 mg	>10 years	5 days	43,900	Yes

CK: creatine kinase; AKI: acute kidney injury; N/A: not available.