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Case Reports in Nephrology
Volume 2011, Article ID 765689, 3 pages
Case Report

The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure

1Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy
2Division of Surgery, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy

Received 15 July 2011; Accepted 8 August 2011

Academic Editors: Y. Fujigaki and A. Shoker

Copyright © 2011 Andrea Bruno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The McKittrick-Wheelock syndrome is a rare cause of severe hydroelectrolyte disorders and fluid depletion as a result of rectal tumor hypersecretion, which can lead to acute renal failure. We report the case of a 70-year-old female who presented with hyponatremia, hypokalemia, hypochloremia, and acute renal failure, due to a watery, mucinous diarrhea. A large rectal villous adenoma was discovered on ileocolonoscopy, and definitive management was achieved by removal of the tumor. In conclusion, reversal of the biochemical derangement is the cornerstone of successful management of the McKittrick-Wheelock syndrome. Then, immediate surgical resection of the tumor is the treatment of choice.