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Case Reports in Nephrology
Volume 2012, Article ID 671595, 5 pages
http://dx.doi.org/10.1155/2012/671595
Case Report

Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy

1Division of Nephrology, Department of Medicine, Western University, London, ON, Canada N6A 3K7
2London Health Sciences Centre, Kidney Clinical Research Unit, Victoria Hospital, Westminster Tower 800 Commissioners Road East, London, ON, Canada N6A 4G5
3Department of Medicine, Western University, London, ON, Canada N6A 3K7

Received 19 February 2012; Accepted 6 May 2012

Academic Editors: Y. Fujigaki, D. Packham, A. Papagianni, and H. Schiffl

Copyright © 2012 Ngan Lam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. M. Nathan, J. B. Buse, M. B. Davidson et al., “Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes,” Diabetes Care, vol. 32, no. 1, pp. 193–203, 2009. View at Google Scholar · View at Scopus
  2. R. A. DeFronzo, “Pharmacologic therapy for type 2 diabetes mellitus,” Annals of Internal Medicine, vol. 131, no. 4, pp. 281–303, 1999. View at Google Scholar · View at Scopus
  3. C. J. Bailey and R. C. Turner, “Metformin,” The New England Journal of Medicine, vol. 334, no. 9, pp. 574–579, 1996. View at Google Scholar · View at Scopus
  4. A. Rathnapala, T. Matthias, and S. Jayasinghe, “Severe lactic acidosis and acute renal failure following ingestion of metformin and kerosene oil: a case report,” Journal of Medical Case Reports, vol. 6, no. 1, article 8, 2012. View at Google Scholar
  5. S. I. Rifkin, C. McFarren, R. Juvvadi, and S. S. Weinstein, “Prolonged hemodialysis for severe metformin intoxication,” Renal Failure, vol. 33, no. 4, pp. 459–461, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Akoglu, B. Akan, S. Piskinpasa et al., “Metformin-associated lactic acidosis treated with prolonged hemodialysis,” American Journal of Emergency Medicine, vol. 29, no. 5, pp. 575.e3–575.e5, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. D. M. Dell'Aglio, L. J. Perino, J. D. Todino, D. A. Algren, and B. W. Morgan, “Metformin overdose with a resultant serum pH of 6.59: survival without sequalae,” Journal of Emergency Medicine, vol. 39, no. 1, pp. e77–e80, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Turkcuer, B. Erdur, I. Sari, A. Yuksel, P. Tura, and S. Yuksel, “Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange,” European Journal of Emergency Medicine, vol. 16, no. 1, pp. 11–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. P. W. Yang, K. H. Lin, S. H. Lo, L. M. Wang, and H. D. Lin, “Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose,” Kaohsiung Journal of Medical Sciences, vol. 25, no. 2, pp. 93–97, 2009. View at Google Scholar · View at Scopus
  10. T. Basturk, B. Balkan, M. Aytekin, A. Unsal, and A. Alagol, “Lactic acidosis due to metformin overdose. What treatment should be? A case report and review of the literature,” BANTAO Journal, vol. 7, pp. 44–46, 2009. View at Google Scholar
  11. M. Galea, N. Jelacin, K. Bramham, and I. White, “Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose,” British Journal of Anaesthesia, vol. 98, no. 2, pp. 213–215, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Y. F. Guo, L. J. Storsley, and S. N. Finkle, “Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin,” Seminars in Dialysis, vol. 19, no. 1, pp. 80–83, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. U. Panzer, S. Kluge, G. Kreymann, and G. Wolf, “Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis,” Nephrology Dialysis Transplantation, vol. 19, no. 8, pp. 2157–2158, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Gjedde, A. Christiansen, S. B. Pedersen, and J. Rungby, “Survival following a metformin overdose of 63 g: a case report,” Pharmacology and Toxicology, vol. 93, no. 2, pp. 98–99, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. C. T. Chang, Y. C. Chen, J. T. Fang, and C. C. Huang, “High anion gap metabolic acidosis in suicide: don't forget metformin intoxication-two patients' experiences,” Renal Failure, vol. 24, no. 5, pp. 671–675, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. K. F. H. Teale, A. Devine, H. Stewart, and N. J. H. Harper, “The management of metformin overdose,” Anaesthesia, vol. 53, no. 7, pp. 698–701, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Heaney, A. Majid, and B. Junor, “Bicarbonate haemodialysis as a treatment of metformin overdose,” Nephrology Dialysis Transplantation, vol. 12, no. 5, pp. 1046–1047, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. J. McLelland, “Recovery from metformin overdose,” Diabetic Medicine, vol. 2, no. 5, pp. 410–411, 1985. View at Google Scholar · View at Scopus
  19. J. Perrone, C. Phillips, and D. Gaieski, “Occult metformin toxicity in three patients with profound lactic acidosis,” Journal of Emergency Medicine, vol. 40, no. 3, pp. 271–275, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. A. M. Arroyo, T. A. Walroth, J. B. Mowry, and L. W. Kao, “The MALAdy of metformin poisoning: is CVVH the cure?” American Journal of Therapeutics, vol. 17, no. 1, pp. 96–100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. J. R. Suchard and T. A. Grotsky, “Fatal metformin overdose presenting with progressive hyperglycemia,” Western Journal of Emergency Medicine, vol. 9, pp. 160–164, 2008. View at Google Scholar
  22. P. Nisse, M. Mathieu-Nolf, M. Deveaux, X. Forceville, and A. Combes, “A fatal case of metformin poisoning,” Journal of Toxicology, vol. 41, no. 7, pp. 1035–1036, 2003. View at Google Scholar · View at Scopus
  23. F. Barrueto, W. J. Meggs, and M. J. Barchman, “Clearance of metformin by hemofiltration in overdose,” Journal of Toxicology, vol. 40, no. 2, pp. 177–180, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. S. R. Salpeter, E. Greyber, G. A. Pasternak, and E. E. Salpeter, “Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD002967, 2010. View at Google Scholar · View at Scopus
  25. N. Peters, N. Jay, D. Barraud et al., “Metformin-associated lactic acidosis in an intensive care unit,” Critical Care, vol. 12, no. 6, article R149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. E. A. Hoste, K. Colpaert, R. C. Vanholder et al., “Sodium bicarbonate versus THAM in ICU patients with mild metabolic acidosis,” Journal of Nephrology, vol. 18, no. 3, pp. 303–307, 2005. View at Google Scholar · View at Scopus