TY - JOUR
A2 - Matsukura, H.
A2 - Trimarchi, H.
A2 - Almirall, J.
A2 - Schiffl, H.
AU - Oberweis, Brandon S.
AU - Mattoo, Aditya
AU - Wu, Ming
AU - Goldfarb, David S.
PY - 2013
DA - 2013/05/21
TI - Minimal Change Disease and IgA Deposition: Separate Entities or Common Pathophysiology?
SP - 268401
VL - 2013
AB - Introduction. Minimal Change Disease (MCD) is the most common cause of nephrotic syndrome in children, while IgA nephropathy is the most common cause of glomerulonephritis worldwide. MCD is responsive to glucocorticoids, while the role of steroids in IgA nephropathy remains unclear. We describe a case of two distinct clinical and pathological findings, raising the question of whether MCD and IgA nephropathy are separate entities or if there is a common pathophysiology. Case Report. A 19-year old man with no medical history presented to the Emergency Department with a 20-day history of anasarca and frothy urine, BUN 68 mg/dL, Cr 2.3 mg/dL, urinalysis 3+ RBCs, 3+ protein, and urine protein : creatinine ratio 6.4. Renal biopsy revealed hypertrophic podocytes on light microscopy, podocyte foot process effacement on electron microscopy, and immunofluorescent mesangial staining for IgA. The patient was started on prednisone and exhibited dramatic improvement. Discussion. MCD typically has an overwhelming improvement with glucocorticoids, while the resolution of IgA nephropathy is rare. Our patient presented with MCD with the uncharacteristic finding of hematuria. Given the improvement with glucocorticoids, we raise the question of whether there is a shared pathophysiologic component of these two distinct clinical diseases that represents a clinical variant.
SN - 2090-6641
UR - https://doi.org/10.1155/2013/268401
DO - 10.1155/2013/268401
JF - Case Reports in Nephrology
PB - Hindawi Publishing Corporation
KW -
ER -