Pulmonary-Renal Syndrome with Negative ANCAs and Anti-GBM Antibody
(a), (b), (c) Light-microscopy examination of renal-biopsy specimens showed proliferative-appearing glomeruli with focal formation of cellular and fibrocellular crescents. The GBM was duplicated. Many glomeruli were globally sclerosed, indicating disease chronicity. (A periodic acid Schiff staining, B periodic acid silver-methenamine staining, C Masson’s trichrome staining). (d) Immunofluorescence microscopy showed slightly bright granular staining for C3 in the mesangium area. (e) Immunofluorescence microscopy showed weak staining with IgG in a linear pattern in part of the GBM. GBM: glomerular basement membrane.
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