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Case Reports in Nephrology
Volume 2014, Article ID 128145, 3 pages
Case Report

A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements

1Department of Medicine, Boston Medical Center, 72 East Concord Street, Evans 124, Boston, MA 02118, USA
2Renal Section, Boston University School of Medicine, 650 Albany Street, Rm 504, Boston, MA 02118, USA

Received 26 June 2014; Accepted 7 August 2014; Published 21 August 2014

Academic Editor: Yen-Ling Chiu

Copyright © 2014 Stephanie M. Toth-Manikowski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute ethylene glycol ingestion classically presents with high anion gap acidosis, elevated osmolar gap, altered mental status, and acute renal failure. However, chronic ingestion of ethylene glycol is a challenging diagnosis that can present as acute kidney injury with subtle physical findings and without the classic metabolic derangements. We present a case of chronic ethylene glycol ingestion in a patient who presented with acute kidney injury and repeated denials of an exposure history. Kidney biopsy was critical to the elucidation of the cause of his worsening renal function.