IgG4-Related Tubulointerstitial Nephritis Associated with Membranous Nephropathy in Two Patients: Remission after Administering a Combination of Steroid and Mizoribine

Table 2

Treatment and the effect of IgG4-related membranous nephropathy reported in previous studies.

Case	References, Year	Age	Gender	IgG4/IgG	TIN	S-Cr (mg/dL)		U-pro (g/day)		f/u (months)	Treatment
		(years)		(mg/dL)		Pre Tx	Post Tx	Pre Tx	Post Tx
1	Uchiyama-Tanaka et al. 2004 [3]	64	Male	665/5410	yes	4.5	1.5	1.5	0.1	2	mPSL
2	Watson et al. 2006 [4]	67	Male	2125/7070	yes	3.4	2.4	2.4	2.5	7	PSL
3	Saeki et al. 2009 [5], Saeki et al. 2010 [6], Saeki et al. 2013 [7]	83	Male	924/3144	yes	1.48	1.22	2.3	1.6	4	PSL
4	Saida et al. 2010 [8], Saeki et al. 2010 [6], Saeki et al. 2013 [7]	78	Male	1860/3731	yes	6.17	HD	1.38	HD	NA	PSL
5	Palmisano et al. 2010 [9]	68	Male	NA	no	1.2	NA	1.5	0.45	NA	ACEI, statins
6	Raissian et al. 2011 [1]	75	Male	NA	yes	6.6	2.5	16	NA	1.1	PSL
7	Raissian et al. 2011 [1], Fervenza et al. 2011 [10], Alexander et al. 2013 [11]	67	Female	531/1581	yes	1.2	1.3	4	0.2	7	PSL
8	Cravedi et al. 2011 [12]	54	Male	730/2022	no	1.15	NA	7.3	8	11	PSL, Rituximab
9	Kawano et al. 2011 [13]	NA	NA	NA	yes	NA	NA	NA	NA	NA	NA
10	Yamaguchi et al. 2012 [14]	60	Female	142/1706	yes	1.05	NA	14	NA	NA	NA
11	Yamaguchi et al. 2012 [14]	64	Male	260/4292	yes	1.4	NA	0.67	NA	NA	NA
12	Jindal et al. 2012 [15]	72	Male	750/1511	yes	4.7	HD	15	HD	NA	PSL, Rituximab
13	Alexander et al. 2013 [11]	75	Male	NA	yes	6.6	2.5	16	3.1	6	PSL
14	Alexander et al. 2013 [11]	53	Male	NA	no	0.8	0.8	16	3.1	46	PSL, MMF
15	Alexander et al. 2013 [11]	50	Male	NA	no	1.3	1.3	3.5	1.5	20	ACEI/ARB, Rituximab, MMF
16	Alexander et al. 2013 [11]	46	Female	NA	yes	NA	Transplant	Nephrotic	0	184	none
17	Alexander et al. 2013 [11]	67	Male	NA	yes	1.8	1.4	4.5	0.7	7	PSL, Cy, ACEI
18	Alexander et al. 2013 [11]	65	Female	NA	yes	0.7	0.8	8.5	2.6	4	PSL, MMF
19	Alexander et al. 2013 [11]	64	Male	NA	yes	3.4	NA	1.7	NA	NA	NA
20	Alexander et al. 2013 [11]	34	Male	NA	no	1.6	NA	12.4	NA	NA	NA
21	Li et al. 2014 [16]	55	Male	1926/5305	yes	0.8	NA	5.5	0.2	20	PSL
22	Miyata et al. 2014 (Case 1)	69	Male	2750/6989	yes	1.0	1.17	1.4	0	48	PSL, MZR, AZA
23	Miyata et al. 2014 (Case 2)	80	Male	1050/6350	yes	0.9	0.78	2.73	0	17	PSL, MZR

Abbreviations: ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; AZA, Azathioprine; Cy, cyclophosphamide; f/u, follow up; HD, hemodialysis; mPSL, methylprednisolone; MMF, Mycophenolate mofetil; MZR, mizoribine; PSL, prednisone/prednisolone; S-Cr, NA, not applicable; serum creatinine; TIN, tubulointerstitial nephritis; U-Pro, urine protein.