Aldosterone Response in Severe Hypokalemia and Volume Depletion: A Case Report and Review of the Recent Research

Figure 2

(a) Angiotensin II and aldosterone response in volume depletion and hypokalemia. (b) Angiotensin II and aldosterone response are affected by both an angiotensin II type 1 receptor blocker and a β-adrenoreceptor antagonist. α-IC, α-intercalated cell; ARB, angiotensin II type 1 receptor blocker; AT1R, angiotensin II type 1 receptor; β-blocker, β-adrenoreceptor antagonist; β-IC, β-intercalated cell; DCT1, initial part of the distal convoluted tubules; ENaC, amiloride-sensitive sodium channel; MR, mineralocorticoid receptor; NCC, thiazide-sensitive NaCl cotransporter; P, phosphorylated; PC, principal cell; ROMK, renal outer medullary potassium channel; WNK, with-no-lysine [K].

(a)

(b)