Cisplatin-Induced Renal Salt Wasting Requiring over 12 Liters of 3% Saline Replacement

Table 1

Hospital course of patient with cisplatin-induced renal salt wasting.

Hospital day	Laboratory findings					Urine volume (mL)	Total  (Na + K) urinary loss (mEq/L)	Management
	SNa (mEq/L)	U(Na + K) (mEq/L)	Uosm (mosm/Kg)	Sosm (mosm/Kg)	SPhos (mg/dL)			Medications	3% NS (mL)
1	138							Cisplatin
2	133
3	125, 122, 119, 124, 123		693	262	3.1				300
4	125, 122		907		2.8	3800	885		800
5	124, 127, 126		806		2.7	4050	923		875
6	129, 133, 128, 132		847		2.8	3100	880		750
7	130, 136		832		3	2450	774		500
8	133, 128, 134		903		2.9	2445	694		670
9	132, 122, 124		760		2.8	2460	693		1400
10	132, 131, 130, 135		636		2.7	2485	646		850
11	134, 133		827		2.9	1630	474	Benazepril	650
12	136, 133		810		2.8	2425	569		500
13	133, 129		768		2.7	1950	598		600
14	134, 131		731		3.1	2500	747	Ibuprofen	0
15	132, 130				3.1	1820	580		1000
16	130, 129		637		3.2	1925	515		500
17	129, 138, 126, 130, 131		734		4.1	2375	679		500
18	131, 131				4.5	2850	649		1000
19	138, 138, 135		783		3.1	2200	679		500
20	135		787			3600	741		0
21	135		540			3670	1049		0
22	130, 129, 131					2650	0		0
23	126, 127		660			1750	469		250
24	131, 131, 127		774			1600	473		250
25	130, 127, 131, 134		625			1750	378		250
26	135, 135		528			1800	392
27	139		404			1700	278
28	137, 130, 134		675			2225	542
29	131, 135					2100	537
30	132					1020
31	138
Total									12145

SNa: serum sodium; U(Na + K): urine sodium plus potassium; Uosm: urine osmolality; Sosm: serum osmolality; SPhos: serum phosphorus; NS: normal saline.