Case Reports in Nephrology / 2018 / Article / Tab 2

Case Report

Severe Symptomatic Hyponatremia Secondary to Escitalopram-Induced SIADH: A Case Report with Literature Review

Table 2

Diagnostic criteria for the syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Essential criteria

1. True plasma hypoosmolality (<275 mOsm/kg H2O)
2. Inappropriate urinary response to hypoosmolality (urine osmolality >100 mOsm/kg H2O)
3. Euvolemia; no edema, ascites, or signs of hypovolemia
4. Elevated urine sodium (>30 mEq/L) during normal sodium and water intake
5. No other causes of euvolemic hyponatremia

Supplemental criteria

1. No significant increase in serum sodium after volume expansion, but improvement with fluid restriction.
2. Unable to excrete >80% of a water load (20 cc/kg) in 4 hours and/or failure to achieve urine osmolality <1mOsm/kg H2O

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