Severe Hypocalcemia and Dramatic Increase in Parathyroid Hormone after Denosumab in a Dialysis Patient: A Case Report and Review of the Literature

Table 1

Laboratory data at baseline and after denosumab therapy.

Laboratory parameters	Before treatment	After denosumab therapy			Reference range
		Day 10	Day 15	Day 30
Corrected Calcium (mg/dL)	9.9	6.9	8.7	9.3	8.4 – 10.2
Phosphorus (mg/dl)	3.8	3.1	3.6	3.6	2.5 – 5.0
Intact PTH (pg/ml)	442	2601	799	349	150 – 300 (Caucasian Dialysis patients)
Alkaline phosphatase (U/L)	96	84	54	49	34- 104
25-OH Vitamin D (ng/ml)	35	_	_	_	30 - 100