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Case Reports in Neurological Medicine
Volume 2011, Article ID 515182, 4 pages
Case Report

CNS Intravascular Lymphoma: A Case Report

1Baton Rouge Neurology Associates, Baton Rouge General Medical Center, 3600 Florida Boulevard, Baton Rouge, LA 70806, USA
2Department of Neurology, University of Kansas Medical Center, Kansas, KS, USA
3Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
4Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
5Neurology Section, VA North Texas Health Care System, Medical Service, Dallas, TX, USA

Received 23 May 2011; Accepted 7 July 2011

Academic Editors: R. Koide, M. Kurz, and M. Turgut

Copyright © 2011 Amer Awad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intravascular lymphoma is a rare but well-described entity. The clinical manifestations are heterogeneous. We report a case of a 59-year-old woman who presented initially with syncope followed by subacute cognitive decline that progressed to minimally conscious state. Shortly after the transfer to our tertiary center the patient died. Brain autopsy disclosed the diagnosis of B-cell intravascular lymphoma. We speculate that syncope could be the first manifestation of central nervous system intravascular lymphoma and should be considered in the differential diagnosis of unexplained syncope. In addition, we stress the importance of early brain biopsy in unexplained white matter disease.