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Case Reports in Neurological Medicine
Volume 2013, Article ID 250865, 2 pages
http://dx.doi.org/10.1155/2013/250865
Case Report

Zolpidem in Progressive Supranuclear Palsy

Department of Neurology, Apollo Hospitals Dhaka, Basundhara R/A, Dhaka 1229, Bangladesh

Received 15 February 2013; Accepted 16 April 2013

Academic Editors: F. C. Henderson, P. Sandroni, and M. Swash

Copyright © 2013 Sandip K. Dash. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder, characterized by motor symptoms, postural instability, personality changes, and cognitive impairment. There is no effective treatment for this disorder. Reduced neurotransmission of GABA in the striatum and globus pallidus may contribute to the symptoms of motor and cognitive symptoms seen in PSP. Zolpidem is a GABA agonist of the benzodiazepine subreceptor BZ1. Here a nondiabetic, normotensive case of PSP is (Progressive Supranuclear Palsy) described, which showed improvement in swallowing, speech, and gaze paresis after zolpidem therapy and possible mechanism of actions are discussed. However, more trials are needed with large number of patients to confirm the effectiveness of zolpidem in progressive supranuclear palsy.