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Case Reports in Neurological Medicine
Volume 2013 (2013), Article ID 590729, 4 pages
http://dx.doi.org/10.1155/2013/590729
Case Report

A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies

1Department of Neurology, Bezmialem Vakıf University, Adnan Menderes Bulvarı, Vatan Caddesi, 34093 Fatih İstanbul, İstanbul, Turkey
2Department of Molecular Biology, Haliç University, Büyükdere Caddesi No. 101, 34394 Mecidiyeköy İstanbul, İstanbul, Turkey
3Department of Neurology, Medeniyet University, Dr. Erkin Caddesi, 34730 Kadıköy İstanbul, İstanbul, Turkey

Received 5 March 2013; Accepted 16 April 2013

Academic Editors: C.-C. Huang and D. J. Rivet

Copyright © 2013 Muhammed Emin Özcan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Complex movement disorder is a relatively rare presentation of neurolupus. Antiphospholipid antibodies are associated with movement disorders likely via aberrant neuronal stimulation. Antiribosomal P antibodies have been previously associated with neuropsychiatric disorders but their correlation with movement disorder was not previously established. Our case report involves a 17-year-old Caucasian female patient positive for only antiribosomal P antibody and lupus anticoagulant who presented with a sudden onset of complex movement disorder. After complete cessation of physical signs with olanzapine, anticardiolipin and anti-β2 glycoprotein I antibodies became positive which indicates a likely discordance between movement disorder and antiphospholipid antibodies. This also indicates a potential causal role of antiribosomal P antibodies in inducing movement disorder.