Case Report

Multiple Sclerosis and Oligodendroglioma: An Exceptional Association

Table 1

Reported cases of MS and pure oligodendroglioma cooccurrence.

AuthorAge at MS onsetAge at tumor diagnosisMS courseTumor clinical presentationMRI main features (other than typical MS findings)Histopathology

Khan et al. [5]4351RRMSNo symptoms (suspicion based on routine MRI)3 cm enhancing lesion involving both white and gray matter in the right parietal lobe*Monomorphic neoplasm composed of oligodendrocytes, GFAP positive, and CD68 negative

Green et al. [6]Case 3450RRMSNo symptoms (suspicion based on routine MRI)Nonenhancing mass lesion involving white matter in the right temporoparietal area, with some sulcal effacement of the overlying cortex*Microcystic low grade oligodendroglioma
Case 44?44?N/ASeizures and monocular inferior left scotoma Right temporal lobe lesion with some mass effect*Grade 2 oligodendroglioma

Giordana et al. [3]3442PPMSN/ABilateral frontal lesion, involving anterior corpus callosum Unclear grade oligodendroglioma, not contiguous with MS lesions

Rao et al. [4]N/A65N/AN/ADiffuse lesion (right > left) across corpus callosum Oligodendroglioma with spotty calcification, ring lesions, contiguous with MS plaques

Barnard and Jellinek [2]2843RR/SC MSN/AMass lesion at the right temporal lobe“Polymorphic” oligodendroglioma with mitotic figures and central necrosis

de la Lama et al. [7]2637RRMSSeizures Large subcortical lesion at the right frontal lobe, poorly enhancing, causing mass effect and midline shifting to the left*Tumoural proliferation with homogeneous nuclei and clear cytoplasms, not contiguous with MS plaques—grade C oligodendroglioma (Smith classification)

*Enlargement from previously known lesion in routine MRI.
N/A: not available; RRMS: relapsing-remitting multiple sclerosis; SC: secondary progressive.